Paola Scaffidi
Francis Crick Institute
43 Papers
129 Citations
Paola Scaffidi is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Chromatin & Cancer. The author has an hindex of 23, co-authored 39 publications. Previous affiliations of Paola Scaffidi include National Institutes of Health & Università telematica San Raffaele.
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Papers
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
TL;DR: It is reported that Hmgb1-/- necrotic cells have a greatly reduced ability to promote inflammation, which proves that the release of HMGB1 can signal the demise of a cell to its neighbours, and cells undergoing apoptosis are programmed to withhold the signal that is broadcast by cells that have been damaged or killed by trauma.
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Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
Tiziana Bonaldi,Fabio Talamo,Paola Scaffidi,Denise Ferrera,Annalisa Porto,Angela Bachi,Anna Rubartelli,Alessandra Agresti,Marco Bianchi +8 more
TL;DR: It is shown here that in all cells HMGB1 shuttles actively between the nucleus and cytoplasm, and secreted when monocytic cells receive an appropriate second signal.
Lamin A-Dependent Nuclear Defects in Human Aging
Paola Scaffidi,Tom Misteli +1 more
TL;DR: It is shown that the same molecular mechanism responsible for HGPS is active in healthy cells, and inhibition of this splice site reverses the nuclear defects associated with aging.
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
Paola Scaffidi,Tom Misteli +1 more
TL;DR: Evidence that progerin interferes with the function of human mesenchymal stem cells (hMSCs) is provided and it is found that expression of proger in hMSCs activates major downstream effectors of the Notch signalling pathway.
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The High Mobility Group (Hmg) Boxes of the Nuclear Protein Hmg1 Induce Chemotaxis and Cytoskeleton Reorganization in Rat Smooth Muscle Cells
Bernard Degryse,Tiziana Bonaldi,Paola Scaffidi,Susanne Müller,Massimo Resnati,Francesca Sanvito,Gianluigi Arrigoni,Marco Bianchi +7 more
TL;DR: HMG1 has all the hallmarks of a molecule that can promote atherosclerosis and restenosis after vascular damage, and it is shown that HMG1 can be released by damage or necrosis of a variety of cell types, including endothelial cells.