Paola Rizzo
University of Ferrara
130 Papers
604 Citations
Paola Rizzo is an academic researcher from University of Ferrara. The author has contributed to research in topics: Notch signaling pathway & Medicine. The author has an hindex of 38, co-authored 117 publications. Previous affiliations of Paola Rizzo include Loyola University Medical Center & Loyola University Chicago.
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Papers
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells.
Sanne Weijzen,Paola Rizzo,Mike Braid,Radhika A. Vaishnav,Suzanne M. Jonkheer,Andrei Zlobin,Barbara A. Osborne,Sridevi Gottipati,Jon C. Aster,William C. Hahn,William C. Hahn,Michael P. Rudolf,Kalliopi P. Siziopikou,W. Martin Kast,Lucio Miele +14 more
TL;DR: It is shown that oncogenic Ras activates Notch signaling and that wild-type Notch-1 is necessary to maintain the neoplastic phenotype in Ras-transformed human cells in vitro and in vivo and suggests that it might be a novel therapeutic target.
623
Rational targeting of Notch signaling in cancer.
TL;DR: Successful targeting of Notch signaling in cancer will require a considerable refinement of the understanding of the regulation of this pathway and its effects in both normal and cancer cells, and opportunities and challenges for Notch-targeted therapies in oncology are described.
424
•Journal Article
Simian virus 40-like DNA sequences in human pleural mesothelioma.
Michele Carbone,Harvey I. Pass,Paola Rizzo,M. Marinetti,M. Di Muzio,Daphne J. Y. Mew,Arthur S. Levine,Antonio Domenico Procopio +7 more
TL;DR: It is suggested that a simian virus 40-like virus may act independently or as a co-carcinogen with asbestos, and the selective large T antigen expression by mesothelioma and not by the surrounding pulmonary parenchyma may have both diagnostic and therapeutic implications.
417
Proteasome Inhibitors Trigger NOXA-Mediated Apoptosis in Melanoma and Myeloma Cells
Jian Zhong Qin,Jeffrey Ziffra,Lawrence S. Stennett,Barbara Bodner,Brian Bonish,Vijaya Chaturvedi,Frank C. Bennett,Pamela M. Pollock,Jeffrey M. Trent,Mary J.C. Hendrix,Paola Rizzo,Lucio Miele,Brian J. Nickoloff +12 more
TL;DR: A novel mechanism for overcoming the apoptotic resistance of tumor cells is provided, and agents triggering NOXA induction are validated as potential selective cancer therapeutics for life-threatening malignancies such as melanoma and multiple myeloma.
353
Lung ultrasound-implemented diagnosis of acute decompensated heart failure in the ED: A SIMEU multicenter study
Emanuele Pivetta,Alberto Goffi,Enrico Lupia,Maria Tizzani,Giulio Porrino,Enrico Ferreri,Giovanni Volpicelli,Paolo Balzaretti,Alessandra Banderali,Antonello Iacobucci,Stefania Locatelli,Giovanna Casoli,Michael B. Stone,Milena Maule,Ileana Baldi,Franco Merletti,Gian Alfonso Cibinel,Paolo Baron,Stefania Battista,Giuseppina Buonafede,Valeria Busso,Andrea Conterno,Paola Rizzo,Patrizia Ferrera,Paolo Fascio Pecetto,Corrado Moiraghi,Fulvio Morello,Fabio Steri,Giovannino Ciccone,Cosimo Calasso,M. Caserta,Marina Civita,Carmen Condo,Vittorio D'Alessandro,Sara Del Colle,Stefania Ferrero,Giulietta Griot,Emanuela Laurita,Alberto Lazzero,Francesca Lo Curto,Marianna Michelazzo,Vincenza Nicosia,Nicola Palmari,Alberto Ricchiardi,Andrea Rolfo,Roberto Rostagno,Fabrizio Bar,Enrico Boero,Mauro Frascisco,Ilaria Micossi,Alessandro Mussa,Valerio Stefanone,Renzo Agricola,Gabriele Cordero,Federica Corradi,Cristina Runzo,Aldo Soragna,Daniela Sciullo,Domenico Vercillo,Attilio Allione,Nicoletta Artana,Fabrizio Corsini,Luca Dutto,Giuseppe Lauria,Teresa Morgillo,Bruno Tartaglino,Daniela Bergandi,Ilaria Cassetta,Clotilde Masera,Mario Garrone,Gianluca Ghiselli,Livia Ausiello,Letizia Barutta,Emanuele Bernardi,Alessia Bono,Daniela Forno,Alessandro Lamorte,Davide Lison,Bartolomeo Lorenzati,Elena Maggio,Ilaria Masi,Matteo Maggiorotto,Giulia Novelli,Francesco Panero,Massimo Perotto,Marco Ravazzoli,E. Saglio,Flavia Soardo,Alessandra Tizzani,Pietro Tizzani,Mattia Tullio,Marco Ulla,Elisa Romagnoli +92 more
TL;DR: The implementation of LUS with the clinical evaluation may improve accuracy of ADHF diagnosis in patients presenting to the ED and had a significantly higher accuracy than a standard workup.
351