Pacome Lecot
Buck Institute for Research on Aging
4 Papers
Pacome Lecot is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: Cell aging & Senescence. The author has an hindex of 2, co-authored 2 publications.
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Papers
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Christopher D. Wiley,Michael C. Velarde,Pacome Lecot,Su Liu,Ethan A. Sarnoski,Adam Freund,Kotaro Shirakawa,Hyung W. Lim,Sonnet S. Davis,Arvind Ramanathan,Akos A. Gerencser,Eric Verdin,Judith Campisi,Judith Campisi +13 more
TL;DR: It is shown that several manipulations that compromise mitochondrial function in proliferating human cells induce a senescence growth arrest with a modified SASP that lacks the IL-1-dependent inflammatory arm, providing a mechanism by which mitochondrial dysfunction can drive aging phenotypes.
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Context-dependent effects of cellular senescence in cancer development.
Pacome Lecot,Fatouma Alimirah,Pierre-Yves Desprez,Pierre-Yves Desprez,Judith Campisi,Judith Campisi,Christopher D. Wiley +6 more
TL;DR: Better understanding the context-dependent effects of cellular senescence may be feasible to limit its detrimental properties while preserving its beneficial effects, and develop novel therapeutic strategies to prevent or treat cancer and possibly other age-associated diseases.
Process Development and Manufacturing: OUTCOMES OF THE T2EVOLVE EUROPEAN SURVEY ON CAR T CELL ANALYTICAL METHODS FROM APHERESIS TO POST-INFUSION IMMUNOMONITORING
Pacome Lecot,Kerstin Neininger,M Lorrain,Laetitia Gambotti,Caroline Dreuillet,Swarup Chatterjee,F. Locatelli,Misen Luu,Carmen Sanges,Michael Hudecek,Arnaud Kremer,Biagio De Angelis,Concetta Quintarelli,Helene Negre +13 more
European survey on CAR T-Cell analytical methods from apheresis to post-infusion immunomonitoring
Biagio De Angelis,M. L. D’Amore,Pacome Lecot,Kerstin Neininger,Margot Lorrain,Laetitia Gambotti,Caroline Dreuillet,Elise Courcault,Sampurna Chatterjee,Julio Delgado,Anne Galy,Paul Franz,Juan R. Rodriguez-Madoz,Yolanda Cabrerizo,A. Richter,Charis Girvalaki,Maddalena Noviello,E. Tassi,C. Sanges,Maik Luu,Michael Hudecek,Andreas Kremer,Franco Locatelli,Hélène Negre,Concetta Quintarelli +24 more