Pablo Ariel
University of North Carolina at Chapel Hill
19 Papers
40 Citations
Pablo Ariel is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Biology & Light sheet fluorescence microscopy. The author has an hindex of 9, co-authored 17 publications. Previous affiliations of Pablo Ariel include Facultad de Ciencias Exactas y Naturales & Rockefeller University.
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Papers
iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging
TL;DR: iDISCO enables facile volume imaging of immunolabeled structures in complex tissues and reveals unexpected variability in number of apoptotic neurons within individual sensory ganglia despite tight control of total number in all ganglia.
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A Selective Activity-Dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis
Shawn M. Ferguson,Gabor Brasnjo,Mitsuko Hayashi,Markus Wölfel,Chiara Collesi,Silvia Giovedì,Andrea Raimondi,Liang Wei Gong,Pablo Ariel,Summer Paradise,Eileen T. O'Toole,Richard A. Flavell,Ottavio Cremona,Gero Miesenböck,Timothy A. Ryan,Pietro De Camilli +15 more
TL;DR: In this article, a neuron-specific guanosine triphosphatase (Dynamin 1) was found to be critically required for the fission reaction of synaptic vesicle endocytosis.
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lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA.
Megan D. Schertzer,Keean C.A. Braceros,Joshua Starmer,Rachel E Cherney,David M Lee,Gabriela Salazar,Megan Justice,Steven R. Bischoff,Dale O. Cowley,Pablo Ariel,Mark J. Zylka,Jill M. Dowen,Terry Magnuson,J. Mauro Calabrese +13 more
TL;DR: It is proposed that CGIs that autonomously recruit PRCs interact with lncRNAs and their associated proteins through three-dimensional space to nucleate the spread of PRCs in lncRNA-targeted domains.
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A beginner's guide to tissue clearing.
TL;DR: A concise summary for the novice describing what tissue clearing is, which research problems it can be applied to, how to decide on a clearing method, and where the field is headed in the future is provided.
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Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon.
Xin Li,Meng Deng,Alex Petrucelli,Cheng Zhu,Jinyao Mo,Lu Zhang,Lu Zhang,Jason W. Tam,Pablo Ariel,Baoyu Zhao,Song Zhang,Hengming Ke,Pingwei Li,Nikolay V. Dokholyan,Nikolay V. Dokholyan,Joseph A. Duncan,Jenny P.-Y. Ting +16 more
TL;DR: It is reported that NLRC3 binds viral DNA and other nucleic acids through its LRR domain with high affinity, wherein viral nucleic acid binding releases an inhibitory innate receptor from its target.
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