Pablo A. Iturra
University of Chile
7 Papers
16 Citations
Pablo A. Iturra is an academic researcher from University of Chile. The author has contributed to research in topics: Mucus & Respiratory system. The author has an hindex of 4, co-authored 5 publications.
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Papers
Near-universal Prevalence of Pneumocystis and Associated Increase in Mucus in the Lungs of Infants with Sudden Unexpected Death
Sergio L. Vargas,Carolina A. Ponce,Miriam Gallo,Francisco J. Pérez,J.-Felipe Astorga,Rebeca Bustamante,Magali Chabé,Isabelle Durand-Joly,Isabelle Durand-Joly,Pablo A. Iturra,Robert F. Miller,El Moukthar Aliouat,Eduardo Dei-Cas,Eduardo Dei-Cas +13 more
TL;DR: It is demonstrated that Pneumocystis reaches a >90% prevalence peak at 3–5 months of age and associates with increased mucus (MUC5AC), suggesting airway epithelium stimulation in infants during this age range and host ability to clear mucus would determine pathogenic expression.
Progression of Type 2 Helper T Cell-Type Inflammation and Airway Remodeling in a Rodent Model of Naturally Acquired Subclinical Primary Pneumocystis Infection.
Pablo A. Iturra,Diego Rojas,Francisco J. Pérez,Andrea Méndez,Carolina A. Ponce,Paula Bonilla,Rebeca Bustamante,H. Rodríguez,Caroll J. Beltrán,Sergio L. Vargas +9 more
TL;DR: Results warrant investigating the clinical impact of this often subclinical infection on the severity of respiratory diseases in early infancy, and this model can also be used to assess the effects of airway insults, including coinfections by recognized respiratory pathogens.
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Fungal colonization with Pneumocystis correlates to increasing chloride channel accessory 1 (hCLCA1) suggesting a pathway for up-regulation of airway mucus responses, in infant lungs
Francisco J. Pérez,Carolina A. Ponce,Diego Rojas,Pablo A. Iturra,Rebeca Bustamante,Myriam Gallo,Karime Hananias,Sergio L. Vargas +7 more
TL;DR: Results strengthen the evidence of Pneumocystis-associated up-regulation of mucus-related airway responses in infant lungs, and further characterization of this immunocompetent host-PneumocyStis-interaction is warranted.
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Niflumic Acid Reverses Airway Mucus Excess and Improves Survival in the Rat Model of Steroid-Induced Pneumocystis Pneumonia.
Francisco J. Pérez,Pablo A. Iturra,Carolina A. Ponce,Fabien Magne,Víctor Antonio García-Angulo,Sergio L. Vargas +5 more
TL;DR: Results suggest an important role of innate immune responses in immunopathology of steroid-induced PcP and warrant evaluation of CLCA1 blockers as adjunctive therapy in this condition and describe a simple model to evaluate therapeutic interventions for steroid resistant mucus.
[Surveillance of adverse effects of Tocilizumab for COVID-19].
TL;DR: The occurrence of ADRs after the use of TCZ is frequent, of mild severity, and in one third of the cases, preventable.
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