Intractable hiccup and nausea (IHN) was found in eight of 47 cases of relapsing neuromyelitis optica (NMO) (17%) but in none of 130 cases of multiple sclerosis (MS). IHN resolved with methylprednisolone. In six cases, MRI detected linear medullary lesions involving the pericanal region, the area postrema, and the nucleus tractus solitarius. Like long and centrally located myelitis, a linear medullary lesion causing IHN may distinguish NMO from MS.

Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica

Intractable hiccups are debilitating and are usually a result of underlying disease. A method of treating chronic hiccups is provided, comprising the steps of applying a peripheral nerve stimulator to the vagus nerve at a predetermined frequency, pulse width, amplitude, and duration; monitoring the occurrence of hiccups in response to said stimulation; and adjusting said frequency, pulse width, amplitude, and duration to reduce the occurrence of said hiccups. The vagus nerve stimulation methods disclosed herein have provided complete resolution to date with a patient with intractable hiccups occurring after a posterior fossa stroke.

Vagus nerve stimulation for chronic intractable hiccups

http://haydnallbutt.com.au/files/review_hiccups.pdf

Persistent hiccup as presenting symptom in medulla oblongata cavernoma: a case report and review of the literature.

The authors report on a 52-year-old woman with a cerebellar hemangioblastoma who presented with a 2-year history of intractable hiccups. Computerized tomography scans and magnetic resonance images revealed a cerebellar hemangioblastoma with compression of the brainstem at the level of the medulla oblongata. The patient has been free of hiccups and has been neurologically intact since the day after total removal of the tumor. A review of the literature on medullary lesions presenting with intractable hiccups is provided.

Intractable hiccups as a presenting symptom of cerebellar hemangioblastoma: Case report

Hiccup and neurosurgeons: a report of 4 rare dorsal medullary compressive pathologies and review of the literature.

Intractable hiccup caused by medulla oblongata lesions.

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Intractable hiccup caused by medulla oblongata lesions.