Ranitidine was first marketed in 1981; since then many patients have been treated such that much experience has been accumulated on the safety of this histamine H2-receptor antagonist in the treatment of gastroduodenal disease. A wide array of ranitidine-associated side effects has been described, but infrequently. As so much information is now available, the aim of this review is to assess the weight of evidence for a causal link between ranitidine and the reported side effects.

Side effects of ranitidine.

Guanfacine and secondary mania in children.

Both ranitidine and metoclopramide produce neuropsychiatric side effects. Concomitant use of these drugs preoperatively may produce adverse behavioral and emotional changes. Therefore in 123 unpremedicated patients undergoing tubal occlusion behavior cognitive function and affect were studied before and after a 2-minute intravenous injection of placebo (n = 30) ranitidine 50 mg (n = 32) metoclopramide 10 mg (n = 30) or both ranitidine 50 mg and metoclopramide 10 mg (n = 31). Cognitive function was evaluated by the responses to 11 statements devised to assess attitude toward anesthesia and surgery. Affect was assessed by the word chosen out of 11 word-pairs as best describing the feelings at the time. After ranitidine injection one patient seemed restless and five seemed drowsy. The changes were associated with subjective feelings of agitation (p < 0.05) and restlessness (p < 0.05). After metoclopramide injection 6 (20%) developed akathisia 13 (43.3%) seemed restless and 8 (26.7%) seemed drowsy. The changes were associated with subjective sensation of jumpiness (p < 0.01) and discomfort (p < 0.05). When both ranitidine and metoclopramide were injected 10 (32.3%) developed akathisia 4 (12.4%) seemed restless and 11 (35.5%) seemed drowsy. The changes were associated with subjective feelings of agitation (p < 0.05) jumpiness (p < 0.05) restlessness (p < 0.01) and upset (p < 0.05). Akathisia a side effect of metoclopramide seemed to be more prominent when ranitidine was added. (authors)

The Effect of Intravenous Ranitidine and Metoclopramide on Behavior, Cognitive Function, and Affect

Mania is a rare complication of prescribed drug use in elderly persons. The drugs most likely to produce mania include corticosteroids and dopamine agonists. It is uncertain if antidepressants cause mania or only increase the propensity for latent bipolar mania to be expressed. Drug-induced mania may promote poor judgment, risk-taking behaviours and medical noncompliance. The majority of episodes of drug-induced mania are short-lived and respond to discontinuation of the drug. Antipsychotic agents may hasten resolution of this psychiatric syndrome. Lithium may prevent corticosteroid-induced mania, but the role of lithium in the treatment of other drug-induced manic episodes has not been studied adequately.

Drug-Induced Mania in the Elderly

Objective:Since 1965, Health and Welfare Canada has operated an adverse drug reaction (ADR) program. The program accepts spontaneous reports of adverse drug reactions, and maintains an ADR database. The purpose of this article is to summarize the Psychiatric ADRs reported to this database since 1965. The nature of the information prohibits its use in the evaluation of epidemiological hypotheses about the etiology of drug-induced mental disorders. However, in an exploratory sense, the contents of the database may contribute to the development of epidemiological hypotheses about the etiology of drug-induced mental disorders. Of particular interest are areas of apparent contradiction between the contents of the database and the clinical literature.Methods:The database was searched for reports of ADRs to a group of drugs which have been frequently implicated in causing psychiatric toxicity. All reports characterized as “psychiatric disorders” were downloaded from the database for the analysis (n = 1822). The ...

Neuropsychiatric Adverse Drug Reactions: Passive Reports to Health and Welfare Canada's Adverse Drug Reaction Database (1965-Present)

Mania-like episodes associated with ranitidine.

Contracture abdomino-crurale au cours de l'insuffisance surrénale: quatre observations et revue de la littérature

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Mania-like episodes associated with ranitidine.

Contracture abdomino-crurale au cours de l'insuffisance surrénale: quatre observations et revue de la littérature