Clinical aspects of adaptation in old age

In a prevalence epidemiologic study conducted in a characteristic submontane area in North Bohemia, the genealogic incidence of myocardial infarction, sudden brain vascular episodes, and malignant tumors was studied in a representative sample of persons aged 70 to 105 years. The incidence was then compared with that in two other samples: 1) men under age 40 with a history of transmural myocardial infarction, and 2) both men and women aged 40–60 who had had a stroke. The statistical evaluation was performed according to accepted international criteria (WHO). A significantly lower genealogic incidence of myocardial infarction and sudden brain vascular episodes was found in the geriatric subjects (70–105 years old) who had symptoms of so-called physiologic aging, as compared with the incidence in the younger subjects who had symptoms of so-called pathologic aging. The difference was less clear-cut with respect to the genealogic incidence of malignant tumors.

Relative Genealogic Incidence of Certain “Civilization Diseases” in a Geriatric Population versus Pregeriatric Groups

A clinico-epidemiologic prevalence survey was conducted in the sub-mountainous area of Northern Bohemia, which is distinguished by the highest proportion of aged people in Bohemian countries. It involved 6057 persons of the 70-79 age group, 1718 persons of the 80-89 age group and 139 persons of the 90+ group, plus control subjects in various other groups. In this study an attempt was made to find an effective measure of the presumed risk factors of pathologic aging in persons of the 70-105 age group. The data were analyzed by the method of coincidence of two parameters of binomial decomposition on the computer Odra. The quantity dependence of the signs was determined, and an index of the compound-risk factor of pathologic aging was calculated. When the numerical value of the index is lower than 56.9 +/- 4.36 for a group of males or 50.3 +/- 3.55 for a group of females, the probability is that a given person in those groups will survive to an advanced age. The total risk is higher for the male sex. Of considerable importance are the genetic burden, external environmental causes, harmful habits, certain "civilization" diseases, and other factors such as disturbed social contacts and defective nutrition.

Some Risk Factors in Pathologic Aging

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Some Risk Factors in Pathologic Aging

Relative Genealogic Incidence of Certain “Civilization Diseases” in a Geriatric Population versus Pregeriatric Groups