Global gene-expression studies have labored to understand the mechanisms of neuronal cell death in many diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and prion disease. In many of these studies, common mechanisms causing neurodegeneration were revealed, such as neuroinflammatory cascades, oxidant as well as antioxidant proteins, apoptotic and antiapoptotic cascades, neuronal differentiation, synaptic trafficking mechanisms, transcription signaling, and ubiquitin–proteasomal cascades. This chapter presents the recent findings of gene-expression profiling in PD animal models, cell culture, and post-mortem sporadic PD subjects substantia nigra pars compacta (SNpc), where the dopamine neurons degenerate. The chapter also compares the findings in different animal and cell culture models and compares the findings to the recent findings in human patients.

Chapter 8 – Genes and Oxidative Stress in Sporadic and Familial Parkinsonism: cDNA Microarray Studies

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Chapter 8 – Genes and Oxidative Stress in Sporadic and Familial Parkinsonism: cDNA Microarray Studies