The primary treatment of acute lymphocytic leukemia (ALL) has been considerably improved. In the first German multicenter study, 01/81 complete remissions have been induced in 272 of 368 patients (73.9%), and in the second study 02/84 in 350 of 442 (79.2%) [1]. Though 35% of the patients remain disease free after 7.5 years in the first study and 48% after 3 years in the second, relapsing and refractory disease is still the most prevalent problem in ALL. The development of effective salvage therapies is warranted. Against this background the German Multicenter ALL Study Group has evaluated an intensive protocol for patients with relapsed or refractory ALL.

Treatment of Relapsed or Refractory Adult Acute Lymphocytic Leukemia

The treatment of acute lymphoblastic leukemia (ALL) with modern multidrug schedules is highly effective. In the first German multicenter study, 01/81, complete remissions were induced in 272 of 368 patients (73.9%), and in the second trial, 02/84, in 350 of 442 (79.2%) [1]. Though 35% of the patients remain disease free after 7.5 years in the first study and 48% after 3 years in the second, relapses are still frequent.

Treatment of relapsed acute lymphocytic leukemia in adults.

In der risikoadaptierten multizentrischen ALL-Therapiestudie des Erwachsenen (02/84) wurde die Wirksamkeit einer Konsolidierungstherapie mit VM26/Ara-C bei Hochrisikopatienten gepruft. Von den 442 rek

Intensivierte Konsolidierungstherapie für ALL-Hochrisikopatienten

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Intensivierte Konsolidierungstherapie für ALL-Hochrisikopatienten