P. Meera Khan
Leiden University
177 Papers
3.5K Citations
P. Meera Khan is an academic researcher from Leiden University. The author has contributed to research in topics: Gene & Familial adenomatous polyposis. The author has an hindex of 42, co-authored 177 publications. Previous affiliations of P. Meera Khan include Netherlands Cancer Institute.
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Papers
Basic defect in the expression of adenosine deaminase in ADA- SCID disease investigated through the cells of an obligate heterozygote.
TL;DR: The in vitro approach through the cells from an obligate heterozygote described in this paper may have a general application in pursuing studies on other cases of inborn errors of metabolism whenever the material from the affected individuals is not available or not suitable for direct investigations.
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Glucose-6-phosphate dehydrogenase deficiency in an Indian rural area
TL;DR: Glucose-6-phosphate dehydrogenase deficiency exists in the Godavari valley in the Eastern Ghats of India and both the partial Negro and the complete Caucasian type are found.
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Orientation of major histocompatibility (MHC) genes relative to the centromere of human chromosome 6
TL;DR: Linkage analysis of the data obtained from a three‐generation Dutch family segregating for genetic variants of centromeric heterochromatic region in the band pi 1 on chromosome 6 (6ph) showed that the genetic distance between the HLA gene cluster and 6ph is about 6 cM, that GLO is closer than HLA to the centromere and that PGM3 is probably not situated on the same chromosomal arm as HLA.
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Electrophoretic characterization and genetics of human biliverdin reductase (BLVR; EC 1.3.1.24); assignment of BLVR to the p14 leads to cen region of human chromosome 7 in mouse-human somatic cell hybrids.
TL;DR: The study indicated that the NADH- as well as the NADPH-dependent BLVR activities are due to one and the same enzyme and that, most probably, only one gene in the human genome codes for BLVR and the BLVR is a monomer in its functional configuration.
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