P. Meera Khan
Leiden University
177 Papers
3.5K Citations
P. Meera Khan is an academic researcher from Leiden University. The author has contributed to research in topics: Gene & Familial adenomatous polyposis. The author has an hindex of 42, co-authored 177 publications. Previous affiliations of P. Meera Khan include Netherlands Cancer Institute.
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Papers
Mechanisms of APC-driven tumorigenesis: lessons from mouse models.
TL;DR: The generation of several mouse models carrying specific Apc mutations on the same inbred genetic background has confirmed the genotype-phenotype correlations initially established among FAP patients, as well as provided important insights into the mechanisms of colorectal tumor formation.
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Linkage studies in autosomal dominant facioscapulohumeral muscular dystrophy
George W. Padberg,Aldur W. Eriksson,W. S. Volkers,Luigi F. Bernini,E. van Loghem,P. Meera Khan,L. E. Nijenhuis,J.C. Pronk,G.M.Th. Schreuder +8 more
TL;DR: Based on scores of other marker genes and on a recombination map of chromosome 14, the probability that the gene for facioscapulohumeral muscular dystrophy is located on chromosome 14 is estimated to be approximately 6%.
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The distribution of esterase D variants in different ethnic groups.
TL;DR: Blood samples collected from a number of human populations belonging to various ethnic groups indicate that the common variant allele ESD2 occurs most frequently in the Mongoloid populations, leastrequently in the Negroid, and with intermediate frequencies in the Caucasoids.
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Inactivation by chloroquine of α-galactosidase in cultured human skin fibroblasts
Philip G. de Groot,Ronald P.J. Oude Elferink,Marja Hollemans,Anneke Strijland,Andries Westerveld,P. Meera Khan,Joseph M. Tager +6 more
TL;DR: Inactivation of α-galactosidase also occurs when homogenates are incubated with chloroquine, but the concentration of the base required for maximum inactivation is at least three orders of magnitude higher than that which must be present in the medium of intact cells to obtain the same effect.
25
Three germline mutations in the TP53 gene
R.S. Cornelis,M. van Vliet,M. J. Van De Vijver,Hans F. A. Vasen,P.A. Voûte,B. Top,P. Meera Khan,Peter Devilee,Cees J. Cornelisse +8 more
TL;DR: While screening for somatic alterations in TP53 in a series of 141 sporadic breast tumors, the authors detected a constitutional missense mutation in codon 235 in a woman diagnosed with breast cancer at age 26 and a recurrence 4 years later, suggesting that the 245 mutation was particularly important for tumor progression.