Purified Actinobacillus actinomycetemcomitans serotype b lipopolysaccharide (LPS) was found to be able to bind Fusobacterium nucleatum cells and to inhibit binding of F. nucleatum to A. actinomycetemcomitans serotype b. Sugar binding studies showed that the requirements for binding of A. actinomycetemcomitans serotype b LPS to the F. nucleatum lectin are the presence of a metal divalent ion, an axial free hydroxyl group at position 4, and free equatorial hydroxyl groups at positions 3 and 6 of d-galactose, indicating that the β-N-acetyl-d-galactosamine in the serotype b LPS trisaccharide repeating unit is the monosaccharide residue recognized by the F. nucleatum lectin. These data strongly suggest that A. actinomycetemcomitans serotype b LPS is one of the receptors responsible for the lactose-inhibitable coaggregation of A. actinomycetemcomitans to fusobacteria.

/pdf/actinobacillus-actinomycetemcomitans-serotype-b-47vvwm3q31.pdf

Actinobacillus actinomycetemcomitans Serotype b Lipopolysaccharide Mediates Coaggregation with Fusobacterium nucleatum

Pústulas acrales como manifestación clave en el diagnóstico de una endocarditis infecciosa subaguda

Acral pustules as the key manifestation in the diagnosis of subacute infective endocarditis

Infective endocarditis is a potentially serious disease that consists of the infection of a heart valve or the mural endocardium altered by prior conditions such as rheumatic fever, congenital valve abnormality, prosthetic valve replacement, parenteral drug use, congenital heart anomalies, or cardiomyopathy.1 The condition is classified as either acute or subacute. The acute form leads rapidly to heart failure within a matter of days, while subacute cases can develop over months as a vague constitutional syndrome. The typical pathogen in acute cases is St aphylococcus aureus, while chronic disease can be due to various agents, including St rept ococcus vir idans in more than 50% of cases, Ent erococcus, and the HACEK group: Haemophilus species,

Acral Pustules as the Key Manifestation in the Diagnosis of Subacute Infective Endocarditis

BACKGROUND: Sporotrichosis is a subacute or chronic disease caused by a dimorphic fungus, Sporothrix schenckii. The first and most traditional treatment is potassium iodide in satured solution (SSKI) used by DE BEURMANN in 1907. For its effectiveness, it is still used for cutaneous sporotrichosis. OBJECTIVE: To evaluate the treatment of cutaneous sporotrichosis with SSKI in relation to clinical cure, side effects, length of treatment and reactivation. METHODS: We conducted a retrospective analysis of medical records over a 24-year period (1981-2005). Patients of all ages who were treated in the hospital´s division of dermatology were included in the study providing that they had a positive culture of S. schenckii. Satured solution of potassium iodide (3 to 6g per day) was the treatment prescribed. For children, half of the dose was prescribed. RESULTS: The lymphocutaneous disease was prevalent, the cure rate was 94.7%, side effects were described in 5.5% of the cases, mean length of treatment was 3.5 months and possible reactivation was observed in 11.1%. CONCLUSION: SSKI is an effective drug, with many side effects, but with low frequency. Resolution was for maximum six months of treatment. SSKI has been found to be a very effective drug in this retrospective study of culture-proven cases of cutaneous and lymphocutaneous sporotrichosis. It should be used as first drug of choice especially in resource-limited settings.

/pdf/cutaneous-sporotrichosis-treatment-with-potassium-iodide-a-33f6w0yz1r.pdf

Cutaneous sporotrichosis treatment with potassium iodide: a 24 year experience in São Paulo state, Brazil

Successful treatment of Actinobacillus actinomycetemcomitans endocarditis with ofloxacin.

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Successful treatment of Actinobacillus actinomycetemcomitans endocarditis with ofloxacin.