P. Leonard
Alfred Hospital
25 Papers
266 Citations
P. Leonard is an academic researcher from Alfred Hospital. The author has contributed to research in topics: Sympathetic nervous system & Essential hypertension. The author has an hindex of 19, co-authored 25 publications.
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Papers
The peripheral kinetics of norepinephrine in depressive illness.
TL;DR: The rapid-removal phase of the disappearance of tritiated norepinephrine from plasma was accelerated in patients with depressive illness, providing presumptive evidence of increased neuronal uptake.
203
Effect of norepinephrine uptake blockers on norepinephrine kinetics
TL;DR: The rapid‐removal phase was sensitive to disturbances in the neuronal uptake of norepinephrine, the t1½ being prolonged by desipramine and lengthened in the patients with peripheral autonomic insufficiency, and the selective extraneuronal nore Pinephrine uptake blocker, cortisol, 500 mg intravenously, had no effect in normal subjects on either plasma norpinephrine clearance or the t2½ value.
96
Effect of propranolol on noradrenaline kinetics in patients with essential hypertension.
TL;DR: During propranolol treatment, noradrenaline spillover rates were in every case within the normal range, much higher than in patients treated with the known sympathetic nervous systems suppressant, clonidine.
66
•Journal Article
Effects of changes in physical activity on blood pressure and sympathetic tone.
TL;DR: Increased physical activity for one month lowers blood pressure in normotensive subjects, and the fall with daily exercise is similar to that after some centrally-acting antihypertensive drugs, and may be due to a reduction in sympathetic nervous activity.
49
•Journal Article
Estimation of 'total' renal, cardiac and splanchnic sympathetic nervous tone in essential hypertension from measurements of noradrenaline release.
TL;DR: The overall rate of release of noradrenaline to plasma was increased in 31 patients with essential hypertension; the median value was 32% (526 pmol/min) higher than in 22 subjects with normal blood pressure.
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