P. J. Barr
University of Birmingham
13 Papers
243 Citations
P. J. Barr is an academic researcher from University of Birmingham. The author has contributed to research in topics: Deoxyuridine & Uracil. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of P. J. Barr include Rega Institute for Medical Research.
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Papers
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.
TL;DR: In animal model systems (namely, cutaneous herpes infections of athymic nude mice), (E)-5-(2-bromovinyl)-dUrd suppressed the development of herpetic skin lesions and mortality therewith associated, whether the compound was administered topically or systemically.
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Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.
TL;DR: When applied topically (at 1% in a water-soluble ointment), phosphonoacetic acid, E-5-(2-bromovinyl)-2'-deoxyuridine, acycloguanosine, and trisodium phosphonoformate emerged as the most active agents.
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The synthesis of nucleosides derived from 5-ethynyluracil and 5-ethynylcytosine
TL;DR: In this article, the trimethylsilyl derivative of 5-ethynylcytosine with appropriate protected sugar derivatives and removal of the protecting groups gave 5-ETHYNYLcytidine, 2′-deoxy-5-ETHNyluracil, and its α-anomer.
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Pharmacokinetics of E-5-(2-Bromovinyl)-2′-Deoxyuridine in Mice
TL;DR: The pharmacokinetics of the newly developed anti-herpes agent, E-5-(2-bromovinyl)-2′-deoxyuridine, was compared with that of the standard anti- herpes drug 5-iodo- 2′- deoxyurazine to find that active blood drug levels could still be found 320 min after oral administration.
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