15 Papers
19 Citations
P.E. Putnam is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Eosinophilic esophagitis & Medicine. The author has an hindex of 7, co-authored 15 publications. Previous affiliations of P.E. Putnam include University of Cincinnati Academic Health Center.
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Papers
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring
Margaret H. Collins,Lisa J. Martin,Eileen S. Alexander,Eileen S. Alexander,J. Todd Boyd,Rachel Sheridan,Hua He,Scott Pentiuk,P.E. Putnam,J. P. Abonia,Vincent A. Mukkada,James P. Franciosi,Marc E. Rothenberg +12 more
TL;DR: The EoE histology scoring system provides a method to objectively assess histologic changes in the esophagus beyond eosinophil number, and discriminates treated from untreated patients, uses features commonly found in such biopsies, and is utilizable by pathologists after minimal training.
Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses
Carine Blanchard,Melissa K. Mingler,Melissa McBride,P.E. Putnam,Margaret H. Collins,G Chang,Keith F. Stringer,J.P. Abonia,Jeffery D. Molkentin,Marc E. Rothenberg +9 more
TL;DR: A novel role for periostin is uncovered in directly regulating leukocyte (eosinophil) accumulation in T helper type 2-associated mucosal inflammation in both mice and humans.
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Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis.
Joseph D. Sherrill,K Kc,David Wu,Zorka Djukic,Julie M. Caldwell,Emily M. Stucke,Katherine A. Kemme,M.S. Costello,Melissa K. Mingler,Carine Blanchard,Margaret H. Collins,J.P. Abonia,P.E. Putnam,Evan S. Dellon,Roy C. Orlando,Simon P. Hogan,M.E. Rothenberg +16 more
TL;DR: A functional role is identified for DSG1 and its dysregulation by IL-13 in the pathophysiology of EoE and it is suggested that the loss ofDSG1 may potentiate allergic inflammation through the induction of pro-inflammatory mediators such as POSTN.
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Dissociation between symptoms and histological severity in pediatric eosinophilic esophagitis.
TL;DR: The data indicate a dissociation between symptoms and histology in pediatric EE, and children with untreated EE had a higher PEESS than treated subjects.
Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing
Joseph D. Sherrill,Kiran Kc,Carine Blanchard,Emily M. Stucke,Katherine A. Kemme,Margaret H. Collins,J.P. Abonia,P.E. Putnam,Vincent A. Mukkada,Ajay Kaul,Samuel A. Kocoshis,Jonathan P. Kushner,Andrew J. Plassard,Rebekah Karns,Phillip J. Dexheimer,Bruce J. Aronow,M.E. Rothenberg +16 more
TL;DR: RNA sequencing on esophageal biopsies from healthy controls and patients with active EoE found several long non-coding RNAs (lncRNA), an emerging class of transcriptional regulators, and the lncRNA BRAF-activated non-protein coding RNA (BANCR), a novel role for lncRNAs in Eo E and IL-13–associated responses.
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