P. E. Chabrier
Ipsen
37 Papers
725 Citations
P. E. Chabrier is an academic researcher from Ipsen. The author has contributed to research in topics: Endothelin receptor & Endothelin 1. The author has an hindex of 20, co-authored 37 publications.
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Papers
Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia.
TL;DR: It is demonstrated that hypoxia-induced pulmonary hypertension is associated with a loss of EDRF activity in pulmonary vessels, with a rapid recovery on return to a normoxic environment.
Different antinociceptive effects of botulinum toxin type A in inflammatory and peripheral polyneuropathic rat models.
TL;DR: It is concluded that BoNT-A elicits antinociceptive effects independent of the effects on muscular relaxation in rat models of carrageenan-induced hyperalgesia and of paclitaxel-induced peripheral neuropathy.
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Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
Liang Tao,Lisheng Peng,Lisheng Peng,Ronnie P.-A. Berntsson,Ronnie P.-A. Berntsson,Sai Man Liu,SunHyun Park,Feifan Yu,Christopher D. Boone,Shilpa Palan,Matthew Beard,P. E. Chabrier,Pål Stenmark,Johannes Krupp,Min Dong +14 more
TL;DR: Mutant botulinum neurotoxin B containing E1191M/S1199Y exhibits ~11-fold higher efficacy in blocking neurotransmission than wild-type botulinu toxin B in neurons expressing human synaptotagmin II, demonstrating that enhancing receptor binding increases the overall efficacy at functional levels.
Elevated tissue endothelin content during focal cerebral ischemia in the rat.
TL;DR: It is demonstrated that during permanent OMCA, the tissue content of ir-ET-1 markedly and progressively increases, whereas less severe ischemia (transient) is accompanied by a modest elevation ofIr- ET-1 levels.
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Lipoteichoic acid: a new inducer of nitric oxide synthase.
Marie Odile Lonchampt,Michel Auguet,Sylvie Delaflotte,J Goulin-Schulz,P. E. Chabrier,Pierre Braquet +5 more
TL;DR: Inducible nitric oxide (NO) synthase in vascular smooth muscle cells (SMCs) appears to play a major role for the diminished responsiveness to vasoconstrictors observed in endotoxemia, but cardiovascular dysfunctions associated with septic shock are also observed in the absence of endotoxin.
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