P. Curotto
National Atomic Energy Commission
31 Papers
45 Citations
P. Curotto is an academic researcher from National Atomic Energy Commission. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 9, co-authored 21 publications.
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Papers
Therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes for oral cancer in the hamster cheek pouch model
Elisa M. Heber,M. Frederick Hawthorne,Peter J. Kueffer,Marcela A. Garabalino,S. Thorp,Emiliano C. C. Pozzi,Andrea Monti Hughes,Charles A. Maitz,Satish S. Jalisatgi,David W. Nigg,P. Curotto,Verónica A. Trivillin,Amanda E. Schwint +12 more
TL;DR: The therapeutic success of BNCT mediated by MAC-TAC liposomes, incorporating K[nido-7-CH3(CH2)15-7,8-C2B9H11] (MAC) in the bilayer membrane and encapsulating the hydrophilic species Na3[ae-B20H17NH3] (TAC) inThe aqueous core, using the hamster cheek pouch oral cancer model is described.
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In vitro studies of DNA damage and repair mechanisms induced by BNCT in a poorly differentiated thyroid carcinoma cell line
Carla Rodríguez,M. Carpano,P. Curotto,S. Thorp,Mariana Casal,G.J. Juvenal,Mario A. Pisarev,Maria Alejandra Dagrosa +7 more
TL;DR: The results showed that the number of nuclear γH2AX foci was higher in the gamma group than in the N and BNCT groups and the expression of Ku70 did not show significant differences between groups, consistent with an activation of HRR mechanism in thyroid cells.
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Closo-Carboranyl- and Metallacarboranyl [1,2,3]triazolyl-Decorated Lapatinib-Scaffold for Cancer Therapy Combining Tyrosine Kinase Inhibition and Boron Neutron Capture Therapy
Marcos Couto,Catalina Alamón,María Fernanda García,Mariángeles Kovacs,Emiliano Trias,S. Nievas,Emiliano C. C. Pozzi,P. Curotto,S. Thorp,Maria Alejandra Dagrosa,Francesc Teixidor,Clara Viñas,Hugo Cerecetto +12 more
TL;DR: A new family of bifunctional compounds, offering the possibility of dual action (drug + radiotherapy combinations), may result in significant clinical benefits and make them interesting agents for combined therapy.
Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: clinical application to boron neutron capture therapy for head and neck cancer.
S. J. González,Emiliano C. C. Pozzi,A Monti Hughes,Lucas Provenzano,Hanna Koivunoro,Daniel Carando,Daniel Carando,S. Thorp,Mariana Casal,Silva Bortolussi,Verónica A. Trivillin,Marcela A. Garabalino,P. Curotto,Elisa M. Heber,G. A. Santa Cruz,L Kankaanranta,Heikki Joensuu,Amanda E. Schwint +17 more
TL;DR: The extension of the photon iso-effective dose model has allowed, for the first time, the determination of the photons iso- effective dose for unacceptable complications in the dose-limiting normal tissue.
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Abscopal effect of boron neutron capture therapy (BNCT): proof of principle in an experimental model of colon cancer.
Verónica A. Trivillin,Emiliano C. C. Pozzi,Lucas L. Colombo,Lucas L. Colombo,S. Thorp,Marcela A. Garabalino,Andrea Monti Hughes,Sara J. González,R.O. Farías,P. Curotto,Gustavo A. Santa Cruz,Daniel Carando,Daniel Carando,Amanda E. Schwint +13 more
TL;DR: The present study performed in a simple animal model provides proof of principle that the positive response of a tumor to BNCT is capable of inducing an abscopal effect.
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