P Costello
Columbia University
9 Papers
17 Citations
P Costello is an academic researcher from Columbia University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 6, co-authored 6 publications.
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Papers
•Journal Article
Expression of myeloid related proteins (MRP) 8 and 14 and the MRP8/14 heterodimer in rheumatoid arthritis synovial membrane.
Peter Youssef,Johannes Roth,Matthew P. Frosch,P Costello,Oliver FitzGerald,Clemens Sorg,Barry Bresnihan +6 more
TL;DR: MRP antigens, representing activation markers on SM macrophages, were observed predominantly in the LL of sections adjacent to the CPJ samples, which suggest altered activation and differentiation of lining layer macrophage at the site of maximal cartilage destruction in RA.
152
Psoriatic arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions appear antigen driven.
P Costello,Robert Winchester,Shane A. Curran,Karin S. Peterson,David J Kane,Barry Bresnihan,Oliver FitzGerald +6 more
TL;DR: The findings support a model of psoriatic arthritis inflammation involving extensive and selective Ag, likely autoantigen, driven intra-articular CD4, and CD8 T cell clonal expansions.
117
Nucleotide Sequencing of Psoriatic Arthritis Tissue before and during Methotrexate Administration Reveals a Complex Inflammatory T Cell Infiltrate with Very Few Clones Exhibiting Features That Suggest They Drive the Inflammatory Process by Recognizing Autoantigens
Shane A. Curran,Oliver FitzGerald,P Costello,Jeanette M. Selby,David J Kane,Barry Bresnihan,Robert Winchester +6 more
TL;DR: TCR β-chain nucleotide sequencing was used to gain insight into the adaptive immune events responsible for Psoriatic arthritis and determine whether the numerous oligoclonal expansions of this disease represent extreme determinant spreading among driving clones that recognize autoantigen or were non-Ag-driven, inflammation-related expansions.
109
Disease Mechanisms in psoriasis and psoriatic arthritis
P Costello,Oliver FitzGerald +1 more
TL;DR: This article reviews the recent literature that advances the understanding of disease mechanisms at these specific sites: the skin, synovium, and enthesis.
12
Influence of menopause and hormone replacement therapy on epidermal ageing and skin biomechanical function
K. Mellody,Alexandra C. Kendall,Jonathan R Wray,April Foster,A.K. Langton,P Costello,Victoria L. Newton,M. Bell,Christopher E.M. Griffiths,Anna Nicolaou,Rachel E.B. Watson,Suzanne M. Pilkington +11 more
TL;DR: This study confirms the efficacy and safety of IL-17 inhibitors in PP and EP patients and shows that patients treated with secukinumab displayed a better clinical response compared with ixekizumab, which was not possible to confirm as previously reported.
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