Disclosed herein are compositions comprising Plinabulin and one or more immune checkpoint inhibitor for treating cancer. Some embodiments relate to methods of treating cancer by co-administering Plinabulin and one or more immune checkpoint inhibitor to a subject in need thereof.

Use of plinabulin in combination with immune checkpoint inhibitors

The present invention discloses a method of treating, preventing or ameliorating tumor growth by immune response modulation via targeting LGALS3BP - CD33 related Siglec pathway using antibody or antibody-drug conjugate therapy. The present invention also provide use of anti-LGALS3BP antibody in combination with an immune checkpoint inhibitor for enhancing, increasing, promoting, expressing, modulating desirable immune response for prevention and treatment of tumors and metastases thereof. Also provides combination therapy with an immune checkpoint inhibitor.

Compositions and methods for preventing tumor growth and treating cancer by targeting lectin galactoside-binding soluble 3 binding protein

La presente invention concerne une methode de traitement, de prevention ou d'amelioration d'un developpement tumoral par la modulation de la reponse immunitaire par le ciblage de la voie des Siglec associee a LGALS3BP-CD33 a l'aide d'une therapie a base d'anticorps ou de conjugues anticorps-medicaments. La presente invention porte egalement sur l'utilisation d'anticorps anti-LGALS3BP en combinaison avec un inhibiteur des points de controle immunitaire pour ameliorer, augmenter, favoriser, exprimer, moduler une reponse immunitaire souhaitable en vue de la prevention et du traitement de tumeurs et de leurs metastases. L'invention concerne egalement une polytherapie impliquant un inhibiteur des points de controle immunitaire.

Compositions et méthodes permettant de prévenir le développement d'une tumeur et de traiter le cancer en ciblant la protéine lgals3bp

Durvalumab. Human anti-PD-L1 monoclonal antibody, Immune checkpoint inhibitor, Oncolytic

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Durvalumab. Human anti-PD-L1 monoclonal antibody, Immune checkpoint inhibitor, Oncolytic