https://www.ajkd.org/article/S0272-6386(03)00828-X/pdf

Hepatitis C and renal disease: an update

MODES OF TRANSMISSION TOBIAS HEINTGES AND JACK R. WANDS HCV is generally transmitted by the parenteral route. Well known and common modes of transmission involve transfuHepatitis C virus (HCV) is an RNA virus with a genomic size of 9.6 kb. More than 50% of individuals exposed to HCV sions and/or parenteral contact with blood products. However, up to 50% of individuals deny exposure to any of these develop chronic infection. Of those individuals chronically infected, approximately 20% to 30% will develop liver cirrhoknown risk factors, and infection is often designated as ‘‘community acquired.’’ Before the initiation of HCV antibody sis and/or hepatocellular carcinoma when followed for twenty to thirty years. Methods to identify HCV include a screening, approximately 10% to 20% of individuals, who had received multiple blood transfusions or plasma products, highly sensitive third generation immunoassay that detects antibodies to structural and nonstructural proteins in serum. seroconverted to anti-HCV positive. Thus, the relative risk was 0.45% per unit transfused. However, the introduction Viremia may be detected by reverse transcriptase–polymerase chain reaction (RT–PCR) technology. The role of HCV of routine HCV antibody screening of blood products has led to a sharp decrease in the transmission rate of HCV. For infection in acute and chronic liver disease has recently be

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.510260338

Hepatitis C virus: Epidemiology and transmission

Value of liver biopsy in the evaluation and management of chronic liver disease in renal transplant recipients

https://www.ajkd.org/article/S0272-6386(01)02061-3/pdf

Hepatitis C virus infection and renal transplantation

Background. Chronic liver disease is one of the most important complications after renal transplantation. Hepatitis B and mainly hepatitis C are the more frequent causes of liver disease. Although there are controversial results, in some series, hepatitis B and hepatitis C are associated with lower graft and patient survival. Patients and methods. A total of 3365 adult patients who received a renal transplant in 1990 (N ¼ 824), 1994 (N ¼ 1075) and 1998 (N ¼ 1466) with a functioning graft after the first year were included. Fifty-one (2.1%) with positive HbsAg were diagnosed with hepatitis B at transplantation; 488 (16.9%) presented positive anti-hepatitis C antibodies and were diagnosed with hepatitis C virus (HCV) infection and 25 patients (0.8%) were diagnosed with concomitant hepatitis B virus (HBV) and HVC infection. Demographic, immunosuppression, survival figures and post-transplant and follow-up data of these patients and negative HBV and HVC patients were recorded. Results. The overall prevalence of HBV in the recipients was 2.1%. Patient survival was lower and liver disease was the main cause of death in HBVpositive patients. However, in the multivariate analysis the presence of positive HbsAg did not have an independent risk factor for graft loss and patient death. This finding was similar in patients with concomitant HBV and HVC infection. Graft and patient survival were lower in HCV-positive patients and liver disease was the main cause of death. Interestingly, proteinuria and serum creatinine were risk factors for graft loss and patient death. Fortunately, prevalence of HCV in the recipients significantly decreased from 29% in 1990 to 10% in 1998. Conclusions. In the last decade in Spain, HBV infection in the recipients, showing an overall prevalence � 2%, did not influence graft and patient survival. However, HCV infection in the recipient was associated with lower graft and patient survival, although the prevalence of HCV clearly decreased from 29% in 1990 to 10% in 1998.

The influence of hepatitis B and hepatitis C virus infection in the recipient on late renal allograft failure

The aim of the study was to analyse the influence of co-infection by hepatitis B virus (HBV) and hepatitis C virus (HCV) as compared with HCV infection alone in 1098 patients who received a kidney transplant between 1 January and 31 December 1991. At transplantation, the prevalence of anti-HCV antibodies was 21.40% (235/1098) while the prevalence of HBV infection was 9.85% (108/1096); 46 patients were co-infected with HBV and HCV, either 19.70% of HCV-infected patients and 42.60% of HBV-infected patients. Liver tests, galactose clearance and liver biopsy were compared in the 46 co-infected patients (HCV+HBV+) and in the 189 HCV-infected patients (HCV+HBV-). At the time of transplantation, cytolysis was present in 31.45% of HCV+HBV- patients (50/159) and in 40% of HCV+HBV- patients (16/40); cholestasis was present in 34.18% of HCV+HBV- patients (34/158) and 42.11% of HCV+HBV+ patients (16/38). At 6 months the incidence of biological abnormalities increased to 37% in HCV+HBV- patients (55/150) and to 52.5% in HCV+HBV+ patients (21/40), suggesting a more deleterious effect of the immunosuppressive therapy in the co-infected group. Over the course of transplantation, chronic hepatitis was present in 50% of HCV+HBV- patients and in 64.1% of HCV+HBV+ patients. Liver failure occurred in 7% of HCV+HBV- patients (12/156) and 17% of HCV+HBV+ patients (7/41). Galactose clearance was performed as a functional test in 68 patients: it was not significantly different in either group. Liver biopsy was performed in 108 patients at least once.(ABSTRACT TRUNCATED AT 250 WORDS)

Co-infection by hepatitis B virus and hepatitis C virus in renal transplantation: morbidity and mortality in 1098 patients

Long-term results in kidney transplantation: patient and graft survival, causes of graft failure and mortality, renal function and complications after 10 years.

Comparison of isolated infection by hepatitis C (HCV) or by hepatitis B (HBV) viruses and of coinfection by HCV-HBV in 1098 renal transplant patients

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

P. Chossegros

Author Tools

Chat about Author

Papers

Co-infection by hepatitis B virus and hepatitis C virus in renal transplantation: morbidity and mortality in 1098 patients

Long-term results in kidney transplantation: patient and graft survival, causes of graft failure and mortality, renal function and complications after 10 years.

Comparison of isolated infection by hepatitis C (HCV) or by hepatitis B (HBV) viruses and of coinfection by HCV-HBV in 1098 renal transplant patients