P Cecchetti
National Research Council
21 Papers
117 Citations
P Cecchetti is an academic researcher from National Research Council. The author has contributed to research in topics: Insulin & Insulin receptor. The author has an hindex of 9, co-authored 20 publications. Previous affiliations of P Cecchetti include University of Pisa.
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Papers
Continually high insulin levels impair Akt phosphorylation and glucose transport in human myoblasts.
A Bertacca,Annamaria Ciccarone,P Cecchetti,Barbara Vianello,Incoronata Laurenza,Margherita Maffei,Chiara Chiellini,Stefano Del Prato,Luca Benzi +8 more
TL;DR: Continuous exposure of cultured myoblasts to high insulin levels induces a persistent up-regulation of IR, IRS1, and PI3K activity associated with the demodulation of insulin signaling, which may contribute to the derangement insulin-signaling pathway states of hyperinsulinemia such as obesity and type 2 diabetes.
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Plasma leptin levels in newborns from normal and diabetic mothers.
Margherita Maffei,L Volpe,G Di Cianni,A Bertacca,Marco Ferdeghini,S Murru,G Teti,I Casadidio,P Cecchetti,R. Navalesi,Luca Benzi +10 more
TL;DR: The results suggest that degree of adiposity is one of the main regulators of leptin concentration in the human newborn and that babies exposed to an altered, though clinically controlled, metabolic environment, as in IDDM mothers, have increased levels of leptin.
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•Journal Article
Effects of metformin therapy on plasma amino acid pattern in patients with maturity-onset diabetes.
Piero Marchetti,Pellegrino Masiello,Luca Benzi,P Cecchetti,Fierabracci,Rosa Giannarelli,F Gregorio,Paolo Brunetti,R. Navalesi +8 more
TL;DR: It is concluded that besides the various metabolic abnormalities that are known to occur during met formin treatment, patients on therapy with metformin also show multiple changes of plasma amino acid pattern.
15
•Journal Article
Diurnal pattern of plasma metformin concentrations and its relation to metabolic effects in type 2 (non-insulin-dependent) diabetic patients.
Piero Marchetti,F Gregorio,Luca Benzi,Rosa Giannarelli,P Cecchetti,G Villani,G. Di Cianni,A. Di Carlo,Paolo Brunetti,R. Navalesi +9 more
TL;DR: The authors describe the diurnal profile of plasma metformin concentrations in a group of 6 Type 2 (noninsulin-dependent) diabetic patients studied at two different daily meetingformin doses and report data on the relationships between plasma met formin and metabolic effects over a 14 h period.
15
Inhibition of endosomal acidification in normal cells mimics the derangements of cellular insulin and insulin-receptor metabolism observed in non—insulin-dependent diabetes mellitus
L. Benzi,L. Benzi,P Cecchetti,P Cecchetti,A.M. Ciccarone,A.M. Ciccarone,A. Nardone,A. Nardone,E. Merola,E. Merola,R. Maggiorelli,R. Maggiorelli,F. Campi,F. Campi,G. Di Cianni,G. Di Cianni,R. Navalesi,R. Navalesi +17 more
TL;DR: The results suggest that the impairment of dissociation of the insulin-insulin receptor complex may play a crucial role in the subsequent altered processing of insulin and insulin receptor and raise the question as to a possible similar alteration of the same intracellular mechanism by NIDDM and monensin.
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