P. Andrew Futreal
University of Texas MD Anderson Cancer Center
350 Papers
1K Citations
P. Andrew Futreal is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 107, co-authored 245 publications. Previous affiliations of P. Andrew Futreal include Wellcome Trust & Wellcome Trust Sanger Institute.
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Papers
Breast cancer genome heterogeneity: a challenge to personalised medicine?
TL;DR: This work states that implementation of high-throughput genomics sequencing approaches into routine laboratory practice has raised the potential for the identification of multiple breast cancer targets suitable for future therapeutic intervention in order to improve cancer outcomes.
Joint multi-omics discriminant analysis with consistent representation learning using PANDA
Jia Wu,M Mohammad Aminu,Lingzhi Hong,Natalie Vokes,Stephanie Schmidt,Maliazurina Saad,Bo Zhu,Tina Cascone,Ajay Sheshadri,David Jaffray,P. Andrew Futreal,Jack Lee,Lauren Byers,Don Gibbons,John Heymach,Ken Chen,Chao Cheng,Jianjun Zhang,Bo Wang +18 more
TL;DR: PANDA is a joint multi-omics discriminant analysis method that jointly learns consistent discriminant latent representations for each omics, minimizing the differences in distributions among omics and maximizing between-class and minimizing within-class omics variations in a common space.
Analysis of genomic and immune intratumor heterogeneity in linitis plastica via multiregional exome and T-cell-receptor sequencing.
Jinsong Huang,Guofeng Zhao,Qiu Peng,Xin Yi,Liyan Ji,Jing Li,Pansong Li,Yanfang Guan,Jie Ge,Ling Chen,Runzhe Chen,Xin Hu,Won-Chul Lee,Alexandre Reuben,P. Andrew Futreal,Xue-ming Xia,Jian Ma,Jianjun Zhang,Zihua Chen +18 more
TL;DR: In this article , the authors performed whole-exome sequencing (WES) and T-cell receptor (TCR) sequencing on 40 tumor regions from four LP patients and found that the landscape and ITH at the genomic and immunologic levels in LP tumors were compared with multiple cancers previously reported.
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer
Ming Chen,Runzhe Chen,Runzhe Chen,Ying Jin,Jun Li,Xin Hu,Jiexin Zhang,Junya Fujimoto,Shawna M Hubert,Bo Zhu,Yanhua Tian,Nicholas McGranahan,Won-Chul Lee,Julie George,Xiao Hu,Yamei Chen,Meijuan Wu,Carmen Behrens,Chi-Wan Chow,Hoa H.N. Pham,Junya Fukuoka,Jia Wu,Edwin R. Parra,Latasha Little,Curtis Gumbs,Xingzhi Song,Chang-Jiun Wu,Lixia Diao,Qi Wang,Robert J. Cardnell,Jianhua Zhang,Jing Wang,Xiuning Le,Don L. Gibbons,John V. Heymach,J. Jack Lee,William N. William,Chao Cheng,Bonnie S. Glisson,Ignacio I. Wistuba,P. Andrew Futreal,Roman K. Thomas,Roman K. Thomas,Alexandre Reuben,Lauren Averett Byers,Jianjun Zhang +45 more
TL;DR: In this article, using multi-region whole exome/T cell receptor (TCR) sequencing as well as immunohistochemistry, a rather homogeneous mutational landscape but extremely cold and heterogeneous TCR repertoire in limited-stage SCLC tumors (LS-SCLCs).
The histologic phenotype of lung cancers may be driven by transcriptomic features rather than genomic characteristics
Ming Tang,Hussein A. Abbas,Marcelo V. Negrao,Maheshwari Ramineni,Xin Hu,Junya Fujimoto,Alexdrandre Reuben,Susan Varghese,Jianhua Zhang,Jun Li,Chi-Wan Chow,Xizeng Mao,Xingzhi Song,Won-Chul Lee,Jia Wu,Latasha Little,Curtis Gumbs,Carmen Behrens,Cesar A. Moran,Annikka Weissferdt,J. Jack Lee,Boris Sepesi,Stephen G. Swisher,John V. Heymach,Ignacio I. Wistuba,P. Andrew Futreal,Neda Kalhor,Jianjun Zhang +27 more
TL;DR: In this paper, the authors conducted whole-exome sequencing (WES) and microarray profiling on 19 micro-dissected tumor regions of different histologic subtypes from 9 patients with lung cancers of mixed histology.