P. Andrew Futreal
University of Texas MD Anderson Cancer Center
350 Papers
1K Citations
P. Andrew Futreal is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 107, co-authored 245 publications. Previous affiliations of P. Andrew Futreal include Wellcome Trust & Wellcome Trust Sanger Institute.
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Papers
Abstract 90: Mining for cancer causing mutations in whole genome sequence data
Andrew Menzies,Philip J. Stephens,David Beare,Adam Butler,Simon A. Forbes,Mingming Jia,David T. Jones,Catherine Leroy,John Marshall,Keiran Raine,Lucy Stebbings,Jon W. Teague,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell +14 more
TL;DR: A variety of automated and semi-automated techniques are employed to identify and classify copy number variation, chromosomal rearrangements, small insertion/deletion and substitution mutations in both cell lines and primary tumours.
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Abstract 630: Interleukin-8 as a potential mediator for renal cell carcinoma resistance to antiangiogenic sunitinib therapy
Dan Huang,Yan Ding,Ming Zhou,Brian I. Rini,David Petillo,Chao-Nan Qian,Richard J. Kahnoski,P. Andrew Futreal,Kyle A. Furge,Bin Tean Teh +9 more
TL;DR: It is demonstrated that IL-8 is an important contributor, among others, to sunitinib resistance in ccRCC, and may serve as a therapeutic target for treatment of sunitInib resistant ccR CC, as well as a biomarker for both acquired and intrinsic sunit inib resistance.
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Correction: Corrigendum: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
Ignacio Varela,Patrick S. Tarpey,Keiran Raine,Dachuan Huang,Choon Kiat Ong,Philip J. Stephens,Helen Davies,David Jones,Meng-Lay Lin,Jon W. Teague,Graham R. Bignell,Adam Butler,Juok Cho,Gillian L. Dalgliesh,Danushka Galappaththige,Christopher Greenman,Claire Hardy,Mingming Jia,Calli Latimer,KingWai Lau,John Marshall,Stuart McLaren,Andrew Menzies,Laura Mudie,Lucy A. Stebbings,David A. Largaespada,L. Wessels,Stéphane Richard,Richard J. Kahnoski,John G. Anema,David A. Tuveson,Pedro A. Perez-Mancera,Ville Mustonen,Andrej Fischer,David J. Adams,Alistair G. Rust,Waraporn Chan-on,Chutima Subimerb,Karl Dykema,Kyle A. Furge,Peter J. Campbell,Bin Tean Teh,Michael R. Stratton,P. Andrew Futreal +43 more
TL;DR: This corrects the article to show that the Higgs boson bacterium is a prokaryotic substance, not a “spatially aggregating substance” as previously reported, which can be a source of disease in animals.
Metagenomes of rectal swabs in larger, advanced stage cervical cancers have enhanced mucus degrading functionalities and distinct taxonomic structure
Tatiana Karpinets,Xiaogang Wu,Travis Solley,Molly B. El Alam,Travis T. Sims,Kyoko Yoshida-Court,Erica Lynn,Mustapha Ahmed-Kaddar,Greyson Biegert,Jingyan Yue,Xingzhi Song,Huandong Sun,Joseph F. Petrosino,Melissa Paola Mezzari,Pablo C. Okhuysen,Patricia J. Eifel,Anuja Jhingran,Lilie L. Lin,Kathleen M. Schmeler,Lois M. Ramondetta,Nadim J. Ajami,Robert R. Jenq,P. Andrew Futreal,Jian Zhang,Ann H. Klopp,Lauren E. Colbert +25 more
TL;DR: In this paper , the authors found significant association of molecular functions encoded by the metagenomes was found with initial tumor size and stage, which was associated with larger, more advanced stage tumors.
Abstract 5108: Copy number analysis of pure DCIS and association with recurrence
Ahmed A Elmgeed Ahmed,Maria Roman-Escorza,Tycho Bismeijer,Michael Sheinman,Vandna Shah,Rana Shami,Jeffrey R. Marks,Lorraine M. King,Anargyros Megalios,Lindy L. Visser,Marlous Hoogstraat,Helen Davies,T. Kumar,Deborah Collyar,Hilary Stobart,Sarah Leigh Pinder,Nicholas N. Navin,P. Andrew Futreal,Serena Nik-Zainal,E. Shelley Hwang,Lodewyk F. A. Wessels,Esther H. Lips,Alastair M. Thompson,Jelle Wesseling,Elinor J. Sawyer +24 more
TL;DR: The aim was to assess whether copy number aberrations (CNAs) could be used to identify DCIS that was likely to recur as invasive disease or remain recurrence-free during long-time follow up and identified potential CNAs that are associated with invasive recurrence.