P. Andrew Futreal
University of Texas MD Anderson Cancer Center
350 Papers
1K Citations
P. Andrew Futreal is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 107, co-authored 245 publications. Previous affiliations of P. Andrew Futreal include Wellcome Trust & Wellcome Trust Sanger Institute.
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Papers
State-of-the-science: An update on renal cell carcinoma
Eric Jonasch,P. Andrew Futreal,Ian J. Davis,Sean T. Bailey,William Y. Kim,James Brugarolas,Amato J. Giaccia,Ghada Kurban,Armin Pause,Judith Frydman,Amado J. Zurita,Brian I. Rini,Pam Sharma,Michael B. Atkins,Cheryl L. Walker,W. Kimryn Rathmell +15 more
TL;DR: An integrated review of the key genomic and molecular biological disease characteristics of ccRCC is created to facilitate interaction among basic, translational, and clinical researchers involved in the treatment of this devastating disease, and accelerate progress toward its ultimate eradication.
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Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer
Alec C. Kimmelman,Aram F. Hezel,Andrew J. Aguirre,Hongwu Zheng,Jihye Paik,Haoqiang Ying,Gerald C. Chu,Jean X. Zhang,Ergun Sahin,Giminna Yeo,Aditya H. Ponugoti,Roustem Nabioullin,Scott Deroo,Shenghong Yang,Xiaoxu Wang,John P. McGrath,Marina Protopopova,Elena Ivanova,Jianhua Zhang,Bin Feng,Ming-Sound Tsao,Mark Redston,Alexei Protopopov,Yonghong Xiao,P. Andrew Futreal,William C. Hahn,David S. Klimstra,Lynda Chin,Lynda Chin,Ronald A. DePinho +29 more
TL;DR: It is determined that RIOK3 promotes its invasive activities through activation of the small G protein, Rac, which prompted a genome wide survey of other components of the Rho family network, revealing p21 Activated Kinase 4 (PAK4) as another amplified gene in PDAC tumors and cell lines.
Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma.
Xin Hu,Junya Fujimoto,Lisha Ying,Junya Fukuoka,Kazuto Ashizawa,Wenyong Sun,Alexandre Reuben,Chi Wan Chow,Nicholas McGranahan,Runzhe Chen,J.S. Hu,Myrna C.B. Godoy,Kazuhiro Tabata,Kishio Kuroda,Lei Shi,Jun Li,Carmen Behrens,Edwin R. Parra,Latasha Little,Curtis Gumbs,Xizeng Mao,Xingzhi Song,Samantha Tippen,Rebecca Thornton,Humam Kadara,Paul Scheet,Emily Roarty,Edwin J. Ostrin,Xu Wang,Brett W. Carter,Mara B. Antonoff,Jianhua Zhang,Ara A. Vaporciyan,Harvey I. Pass,Stephen G. Swisher,John V. Heymach,J. Jack Lee,Ignacio I. Wistuba,Waun Ki Hong,P. Andrew Futreal,Dan Su,Jianjun Zhang +41 more
TL;DR: Multi-region exome sequencing is performed of 116 resected lung nodules to discern the evolutional trajectory from precancers to invasive lung cancers and shows evidence of convergent evolution.
Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual disability
Cheryl Shoubridge,Cheryl Shoubridge,Patrick S. Tarpey,Fatima Abidi,Sarah L. Ramsden,Sinitdhorn Rujirabanjerd,Sinitdhorn Rujirabanjerd,Jessica A. Murphy,Jackie Boyle,Marie Shaw,Alison Gardner,Anne Proos,Helen Puusepp,F. Lucy Raymond,Charles E. Schwartz,Roger E. Stevenson,Gill Turner,Michael Field,Randall S. Walikonis,Robert J. Harvey,Anna Hackett,P. Andrew Futreal,Michael R. Stratton,Jozef Gecz,Jozef Gecz +24 more
TL;DR: It is shown that a mutation of IQSEC2, encoding a guanine nucleotide exchange factor for the ADP-ribosylation factor family of small GTPases, caused MRX1, the X chromosome exome resequencing disorder.
Deep sequencing of circulating tumor DNA detects molecular residual disease and predicts recurrence in gastric cancer.
Jian Yang,Yuhua Gong,Vincent K. Lam,Yan Shi,Yanfang Guan,Yanyan Zhang,Liyan Ji,Yongsheng Chen,Yong-liang Zhao,Feng Qian,Jun Chen,Pingang Li,Fan Zhang,Wang Jiayin,Zhang Xuanping,Ling Yang,Scott Kopetz,P. Andrew Futreal,Jianjun Zhang,Xin Yi,Xuefeng Xia,Peiwu Yu +21 more
TL;DR: Results indicate that ctDNA-detected MRD identifies patients at high risk for recurrence and can facilitate novel treatment intensification studies in the adjuvant setting to improve survival.