Oyinkan Sofola-Adesakin
University College London
6 Papers
8 Citations
Oyinkan Sofola-Adesakin is an academic researcher from University College London. The author has contributed to research in topics: Amyloid beta & Neurodegeneration. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Oyinkan Sofola-Adesakin include Max Planck Society & University of Sussex.
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Papers
Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models.
TL;DR: Generic mechanisms by which lithium preserves neuronal function and improves memory in animal models of dementia are focused on, which have advantages as a multi-functional therapy to combat the complex molecular pathology of dementia.
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pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity.
Oyinkan Sofola-Adesakin,Mobina Khericha,Mobina Khericha,Inge Snoeren,Inge Snoeren,Leo Tsuda,Linda Partridge,Linda Partridge +7 more
TL;DR: This study characterized the Drosophila model of AβpE3-42 toxicity by expressing the peptide in specific sets of neurons using the GAL4-UAS system, and measuring different phenotypic outcomes, and found that A βpE 3-42 peptide had an increased propensity to aggregate.
Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity.
Teresa Niccoli,Fiona Kerr,Fiona Kerr,Fiona Kerr,Inge Snoeren,Daniel K. Fabian,Benjamin Aleyakpo,Dobril Ivanov,Dobril Ivanov,Oyinkan Sofola-Adesakin,Adam Cryar,Jennifer Adcott,Janet M. Thornton,Linda Partridge,Linda Partridge +14 more
- 01 Jan 2021
TL;DR: Caution is suggested in the use of therapeutic strategies focussed on down-regulation of this pathway for the treatment of Alzheimer's disease, since its natural response to the toxic peptide may induce beneficial neuroprotective effects.
Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity
Marianna Karina Gorsky,Sylvie Burnouf,Oyinkan Sofola-Adesakin,Jacqueline Dols,Hrvoje Augustin,Carina Marianne Weigelt,Sebastian Grönke,Linda Partridge +7 more
TL;DR: Results indicate acetylation of hTau on multiple sites regulates its biology and ameliorates amyloid beta toxicity in vivo, and potentially avoids potential toxicity due to genetic over-expression.
Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease
Oyinkan Sofola-Adesakin,Jorge Iván Castillo-Quan,Charalampos Rallis,Luke S Tain,Ivana Bjedov,Iain Rogers,Li Li,Pedro Martinez,Mobina Khericha,Melissa Cabecinha,Jurg Bahler,Linda Partridge +11 more
TL;DR: It is found that lithium caused a reduction in protein synthesis in Drosophila and hence the level of Aβ42, which highlights a role for lithium and reduced protein synthesis as potential therapeutic targets for AD pathogenesis.