Owen Thompson
University of Washington
9 Papers
8 Citations
Owen Thompson is an academic researcher from University of Washington. The author has contributed to research in topics: Population & Gene. The author has an hindex of 8, co-authored 9 publications.
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Papers
The Million Mutation Project: A new approach to genetics in Caenorhabditis elegans
Owen Thompson,Mark L. Edgley,Pnina Strasbourger,Stephane Flibotte,Brent Ewing,Ryan Adair,Vinci Au,Iasha Chaudhry,Lisa Fernando,Harald Hutter,Armelle Kieffer,Joanne Lau,Norris Lee,Angela Miller,Greta Raymant,Bin Shen,Jay Shendure,Jon Taylor,Emily H. Turner,LaDeana W. Hillier,Donald G. Moerman,Robert H. Waterston +21 more
TL;DR: A nonsense suppressor is revealed as well as strains with higher levels of indels that harbor mutations in DNA repair genes and strains with abundant males associated with him mutations, providing an unprecedented genetic resource for this multicellular organism.
Comparative analysis of the transcriptome across distant species
Mark Gerstein,Joel Rozowsky,Koon-Kiu Yan,Daifeng Wang,Chao Cheng,James B. Brown,James B. Brown,Carrie A. Davis,LaDeana W. Hillier,Cristina Sisu,Jingyi Jessica Li,Jingyi Jessica Li,Baikang Pei,Arif Harmanci,Michael O. Duff,Sarah Djebali,Roger P. Alexander,Burak H. Alver,Raymond K. Auerbach,Kimberly Bell,Peter J. Bickel,Max E. Boeck,Nathan Boley,Nathan Boley,Benjamin W. Booth,Lucy Cherbas,Peter Cherbas,Chao Di,Alexander Dobin,Jorg Drenkow,Brent Ewing,Gang Fang,Megan Fastuca,Elise A. Feingold,Adam Frankish,Guanjun Gao,Peter J. Good,Roderic Guigó,Ann S. Hammonds,Jen Harrow,Roger A. Hoskins,Cédric Howald,Cédric Howald,Long Hu,Haiyan Huang,Tim Hubbard,Tim Hubbard,Chau Huynh,Sonali Jha,Dionna M. Kasper,Masaomi Kato,Thomas C. Kaufman,Robert R. Kitchen,Erik Ladewig,Julien Lagarde,Eric C. Lai,Jing Leng,Zhi Lu,Michael J. MacCoss,Gemma E. May,Gemma E. May,Rebecca McWhirter,Gennifer E. Merrihew,David M. Miller,Ali Mortazavi,Rabi Murad,Brian Oliver,Sara Olson,Peter J. Park,Michael J. Pazin,Norbert Perrimon,Norbert Perrimon,Dmitri D. Pervouchine,Valerie Reinke,Alexandre Reymond,Garrett Robinson,Anastasia Samsonova,Anastasia Samsonova,Gary Saunders,Gary Saunders,Felix Schlesinger,Anurag Sethi,Frank J. Slack,William C. Spencer,Marcus H. Stoiber,Marcus H. Stoiber,Pnina Strasbourger,Andrea Tanzer,Andrea Tanzer,Owen Thompson,Kenneth H. Wan,Guilin Wang,Huaien Wang,Kathie L. Watkins,Jiayu Wen,Kejia Wen,Chenghai Xue,Li Yang,Li Yang,Kevin Y. Yip,Chris Zaleski,Yan Zhang,Henry Zheng,Steven E. Brenner,Brenton R. Graveley,Susan E. Celniker,Thomas R. Gingeras,Robert H. Waterston +107 more
TL;DR: It is found in all three organisms that the gene-expression levels, both coding and non-coding, can be quantitatively predicted from chromatin features at the promoter using a ‘universal model’ based on a single set of organism-independent parameters.
Remarkably divergent regions punctuate the genome assembly of the Caenorhabditis elegans Hawaiian strain CB4856
Owen Thompson,L. Basten Snoek,Harm Nijveen,Mark G. Sterken,Rita J. M. Volkers,Rachel Brenchley,Arjen van 't Hof,Roel P. J. Bevers,Andrew R. Cossins,Itai Yanai,Alex Hajnal,Tobias Schmid,Jaryn D. Perkins,David H. Spencer,Leonid Kruglyak,Erik C. Andersen,Donald G. Moerman,LaDeana W. Hillier,Jan E. Kammenga,Robert H. Waterston +19 more
TL;DR: The draft sequence makes available a comprehensive catalog of sequence differences between the CB4856 and N2 strains that will facilitate the molecular dissection of their phenotypic differences, and emphasizes the importance of going beyond simple alignment of reads to a reference genome when assessing differences between genomes.
MIP-MAP: High-Throughput Mapping of Caenorhabditis elegans Temperature Sensitive Mutants via Molecular Inversion Probes
Calvin Mok,Vinci Au,Owen Thompson,Mark L. Edgley,Louis Gevirtzman,John Yochem,Joshua B. Lowry,Nadin Memar,Matthew R. Wallenfang,Dominique Rasoloson,Bruce Bowerman,Ralf Schnabel,Geraldine Seydoux,Donald G. Moerman,Robert H. Waterston +14 more
TL;DR: The results suggest this collection of strains contains a diverse library of TS alleles for genes involved in development and reproduction, and the MIP-MAP protocol is a robust method to genetically map mutations in both viable and essential genes.
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Isolation of specific neurons from C. elegans larvae for gene expression profiling.
W. Clay Spencer,Rebecca McWhirter,Tyne Miller,Pnina Strasbourger,Owen Thompson,LaDeana W. Hillier,Robert H. Waterston,David M. Miller +7 more
TL;DR: A simple and robust protocol for expression profiling studies of post-embryonic C. elegans neurons and thus provides an important new method for identifying candidate genes for key roles in neuron-specific development and function.