Owen Cornwell
AstraZeneca
8 Papers
18 Citations
Owen Cornwell is an academic researcher from AstraZeneca. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 2, co-authored 6 publications. Previous affiliations of Owen Cornwell include University of Leeds.
Chat about Author
Papers
Comparing Hydrogen Deuterium Exchange and Fast Photochemical Oxidation of Proteins: a Structural Characterisation of Wild-Type and ΔN6 β 2 -Microglobulin.
TL;DR: It is demonstrated that, with carefully optimised LC-MS conditions, FPOP data can probe solvent accessibility at the sub-amino acid level, and that these data can be interpreted meaningfully to gain more detailed understanding of the local environment and orientation of the side chains in protein structures.
47
Long-Range Conformational Changes in Monoclonal Antibodies Revealed Using FPOP-LC-MS/MS.
TL;DR: Identifying the differences in oxidative labelling between the two antibodies at residue level revealed long-range effects which provide a key insight into their conformational differences, suggesting a change in the structure and orientation of the CL - CH1 interface.
22
AZD7442 demonstrates prophylactic and therapeutic efficacy in non-human primates and extended half-life in humans
Yueh-Ming Loo,Patrick M. McTamney,Rosalinda H Arends,Robert A. Gasser,Michael E Abram,Anastasia Aksyuk,Seme Diallo,Daniel J Flores,Elizabeth J. Kelly,Kuishu Ren,Richard Roque,Kim Rosenthal,Katie Streicher,Kevin M Tuffy,Nicholas J. Bond,Owen Cornwell,Jerome Bouquet,Lily Cheng,James Dunyak,Yue Huang,Anton I. Rosenbaum,Hanne Andersen,Robert H. Carnahan,James E. Crowe,James E. Crowe,Ana I. Kuehne,Andrew S. Herbert,John M. Dye,Helen Bright,Nicole L. Kallewaard,Menelas N. Pangalos,Mark T. Esser +31 more
TL;DR: AzD7442 as discussed by the authors is a combination of two monoclonal antibodies (mAbs) against SARS-CoV-2, which can prevent and treat COVID-19, and reduce the risk of severe disease and death.
Investigation of D76N β2-Microglobulin Using Protein Footprinting and Structural Mass Spectrometry.
TL;DR: In this paper, the authors employed two protein footprinting methods, hydrogen-deuterium exchange (HDX) and fast photochemical oxidation of proteins (FPOP), in conjunction with ion mobility-mass spectrometry, to probe the differences in conformational dynamics of the two proteins.
4
Fast photochemical oxidation of proteins coupled with mass spectrometry.
Owen Cornwell,James R. Ault +1 more
- 01 Aug 2022
TL;DR: Fast photochemical oxidation of proteins (FPOP) is a hydroxyl radical footprinting approach whereby radicals, produced by UV laser photolysis of hydrogen peroxide, induce oxidation of amino acid side-chains as discussed by the authors .
4