Oualid Talhi
University of Aveiro
56 Papers
107 Citations
Oualid Talhi is an academic researcher from University of Aveiro. The author has contributed to research in topics: Chemistry & Chromone. The author has an hindex of 10, co-authored 54 publications.
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Papers
A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+
Amar Djemoui,Abdelkader Naouri,Mohammed Ridha Ouahrani,Djamila Djemoui,Souli Lahcene,Mokhtar Boualem Lahrech,Leila Boukenna,Hélio M. T. Albuquerque,Liza Saher,Djenisa H. A. Rocha,Fátima Liliana Monteiro,Luisa A. Helguero,Khaldoun Bachari,Oualid Talhi,Artur M. S. Silva +14 more
TL;DR: In this article, a series of triazole-benzimidazile-chalcone hybrid compounds have been synthesized via click chemistry, between different azide derivatives and substituted benzimide terminal alkynes bearing a chalcone moiety.
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Advances in Spirocyclic Hybrids: Chemistry and Medicinal Actions.
Mohammed Benabdallah,Oualid Talhi,Fatiha Nouali,Nouredine Choukchou-Braham,Khaldoun Bachari,Artur M. S. Silva +5 more
TL;DR: A structural diversity of spirocyclic hybrids has proved neuroprotective effects, anti-HIV, antiviral and antibacterial activities, which render them impressive synthetic hits for innovative drug conception.
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Novel benzofuran–chromone and –coumarin derivatives: synthesis and biological activity in K562 human leukemia cells
Clemens Zwergel,Sergio Valente,Sergio Valente,Angela Salvato,Zhanjie Xu,Oualid Talhi,Antonello Mai,Artur M. S. Silva,Lucia Altucci,Gilbert Kirsch +9 more
TL;DR: A series of 26 novel benzofuran derivatives with the first biological results in K562 human leukemia cells showing that compounds 21b, 29b and 29c are able to induce around 24% apoptosis.
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One‐Pot Synthesis of Benzopyran‐4‐ones with Cancer Preventive and Therapeutic Potential
Oualid Talhi,Lidia Brodziak-Jarosz,Jana Panning,Barbora Orlikova,Clemens Zwergel,Clemens Zwergel,Tzvetomira Tzanova,Stéphanie Philippot,Diana C. G. A. Pinto,Filipe A. Almeida Paz,Clarissa Gerhäuser,Tobias P. Dick,Claus Jacob,Marc Diederich,Denyse Bagrel,Gilbert Kirsch,Artur M. S. Silva +16 more
TL;DR: Of the seven compounds evaluated for antiproliferative activities, 3k and 3r were the most active, inhibiting leukaemia K562 cell proliferation by 50% after 72 h at concentrations of 4.5 and 7.9 mu M, whereas normal peripheral blood mononuclear cells were not affected.
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Hydroxycoumarin OT-55 kills CML cells alone or in synergy with imatinib or Synribo: Involvement of ER stress and DAMP release.
Aloran Mazumder,Jin Young Lee,Oualid Talhi,Claudia Cerella,Sébastien Chateauvieux,Anthoula Gaigneaux,Che Ry Hong,Hyoung Jin Kang,Youngjo Lee,Kyu-Won Kim,Dong-Wook Kim,Hee Young Shin,Mario Dicato,Khaldoun Bachari,Artur M. S. Silva,Barbora Orlikova-Boyer,Marc Diederich +16 more
TL;DR: OT-55 triggered ER stress leading to canonical, caspase-dependent apoptosis and release of danger associated molecular patterns, and promoted phagocytosis of OT-55-treated CML cells by both murine and human monocyte-derived macrophages.
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