Otto Majdic
Medical University of Vienna
64 Papers
1K Citations
Otto Majdic is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 32, co-authored 64 publications.
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Papers
B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction.
Judith Leitner,Christoph Klauser,Winfried F. Pickl,Johannes Stöckl,Otto Majdic,Anaïs F. Bardet,David P. Kreil,Chen Dong,Tomohide Yamazaki,Gerhard J. Zlabinger,Katharina Pfistershammer,Peter Steinberger +11 more
TL;DR: It is demonstrated that B7‐H3–T‐cell interaction is characterised by an early suppression of IL‐2 and that T‐cell inhibition can be reverted by exogenous IL-2, and a potential functional dualism is addressed.
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1.
Sabrina Jutz,Judith Leitner,Klaus G. Schmetterer,Iago Doel-Perez,Otto Majdic,Katharina Grabmeier-Pfistershammer,Wolfgang Paster,Johannes B. Huppa,Peter Steinberger +8 more
TL;DR: The generation of a triple parameter reporter based on the human Jurkat T cell line is described, where response elements for NF-κB, NFAT and AP-1 drive the expression of the fluorescent proteins CFP, eGFP and mCherry, respectively, and has a wide range of applications beyond the evaluation of costimulatory pathways.
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T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density
Christian Koch,Günther Staffler,Robert Hüttinger,Ivan Hilgert,Elisabeth Prager,Jan Černý,Peter Steinlein,Otto Majdic,Václav Hořejší,Hannes Stockinger +9 more
TL;DR: Evidence is provided that induction of ordered dimerization of CD147 by a mAb directed to a unique epitope results in strong inhibition of CD3-mediated T cell activation.
•Journal Article
Identification of CD68+lin- peripheral blood cells with dendritic precursor characteristics.
Herbert Strobl,Clemens Scheinecker,Elisabeth Riedl,Bettina Csmarits,Concha Bello-Fernandez,Winfried F. Pickl,Otto Majdic,Walter Knapp +7 more
TL;DR: A minor population of strongly CD68-positive (CD68bright) blood cells that lack all analyzed myeloid surface and lysosomal lineage marker molecules are demonstrated, suggesting that these cells arise from a novel nonmyeloid human DC differentiation pathway.
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Further characterization of surface membrane structures expressed on human basophils and mast cells.
TL;DR: Results provide further evidence that both blood basophils and mast cells express a unique immunologic surface marker profile including binding sites for a variety of immunomodulating ligands and adhesion molecules.
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