Otto Dahl
University of Copenhagen
177 Papers
1.7K Citations
Otto Dahl is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Oligonucleotide & Thymine. The author has an hindex of 25, co-authored 177 publications.
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Papers
Increased DNA binding and sequence discrimination of PNA oligomers containing 2,6-diaminopurine.
TL;DR: A homopurine decamer PNA containing six diaminopurines is shown to form a (gel shift) stable strand displacement complex with a target in a 246 bp double-stranded DNA fragment.
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Recognition of single-stranded DNA by nuclease P1: high resolution crystal structures of complexes with substrate analogs.
TL;DR: Modelling of a productive P1‐substrate complex based on the solved structures suggests steric hindrance as the likely reason for the resistance of Rp‐phosphorothioates and phosphorodithioates.
109
Mechanistic studies on the phosphoramidite coupling reaction in oligonucleotide synthesis. I. Evidence for nucleophilic catalysis by tetrazole and rate variations with the phosphorus substituents
TL;DR: The inhibitor properties of dialkylammonium tetrazolides have practical consequences for the efficiency of DNA syntheses, when in situ prepared phosphoramidites are used; the same would apply for segmented, simultaneous syntheses or syntheses where recycling is performed.
109
Peptide nucleic acids (pnas) with a functional backbone
TL;DR: In this article, the synthesis of 10 new T-PNA monomers derived from L-amino acids is presented, which are incorporated into decameric PNA oligomers, and the hybridisation with RNA, DNA and PNA complements studied by thermal stability measurements.
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