Interleukin-7: from bench to clinic.

Interleukin-7: master regulator of peripheral T-cell homeostasis?

Interleukin-7 restores immunity in athymic T-cell-depleted hosts.

Interleukin 7 worsens graft-versus-host disease.

Murine reconstitution assays were used to investigate the effects of recombinant human interleukin-7 (rhIL-7) on myeloid and lymphoid precursors and on bone marrow engraftment. Reconstitution with bone marrow from rhIL-7-treated mice results in a 3.4-fold decrease in total colony-forming unit-spleen (CFU-S) activity (day 9) and an 18.1- and 11.9-fold decrease in its ability to generate thymocytes and splenic B lineage cells, respectively. In contrast, after reconstitution with splenocytes from rhIL-7-treated mice, CFU-S activity increased 23.6-fold (day 9) and the thymocyte and splenic B lineage cell regenerative capacity increased by 4.0- and 3.2-fold, respectively. In addition, CD43low+, B220low+ cells that contain pre-pro-B cells and pro-B cells were expanded two- to threefold and Ig mu-, B220+, CD2- and Ig mu-, B220+, CD2+ B lineage cells were expanded approximately 10-fold and 10- to 45-fold (depending on the tissue examined), respectively, after rhIL-7 treatment. Administration of rhIL-7 to irradiated mice transplanted with bone marrow resulted in accelerated T cell and B cell reconstitution by up to 2-4 weeks. Thus, rhIL-7 administration affects the distribution of myeloid and lymphoid precursors. Moreover, rhIL-7 administration accelerates murine bone marrow cell engraftment and therefore may be useful in reducing the engraftment time in bone marrow transplant patients.

Recombinant human IL-7 administration in mice affects colony-forming units-spleen and lymphoid precursor cell localization and accelerates engraftment of bone marrow transplants

Murine reconstitution assays were used to investigate the effects of recombinant human interleukin- 7 (rhIL-7) on myeloid and lymphoid precursors and on bone marrow engraftment. Reconstitution with bone marrow from rhIL-7-treated mice results in a 3.4-fold decrease in total colony-forming unit-spleen (CFU-S) ac­ tivity (day 9) and an 18.1- and 11.9-fold decrease in its ability to generate thymocytes and splenic B lineage cells, respectively. In contrast, after reconstitution with spleno- cytes from rhIL-7-treated mice, CFU-S activity increased 23.6-fold (day 9) and the thymocyte and splenic B lineage cell regenerative capacity increased by 4.0- and 3.2-fold, respectively. In addition, CD43Iow+, B220lowf cells that contain pre-pro-B cells and pro-B cells were expanded two- to threefold and Ig(X', B220+, CD2" and Ig|T, B220+, CD2+ B lineage cells were expanded approximately 10- fold and 10- to 45-fold (depending on the tissue exam­ ined), respectively, after rhIL-7 treatment. Administration of rhIL-7 to irradiated mice transplanted with bone mar­ row resulted in accelerated T cell and B cell reconstitu­ tion by up to 2-4 weeks. Thus, rhIL-7 administration affects the distribution of myeloid and lymphoid precur­ sors. Moreover, rhIL-7 administration accelerates murine bone marrow cell engraftment and therefore may be useful in reducing the engraftment time in bone marrow transplant patients. J. Leukoc. Biol 58: 151-158; 1995.

localization a nd a ccelerates engraftment o f b one marrow t ransplants

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Recombinant human IL-7 administration in mice affects colony-forming units-spleen and lymphoid precursor cell localization and accelerates engraftment of bone marrow transplants

localization a nd a ccelerates engraftment o f b one marrow t ransplants