It has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by implantation, preferably subcutaneously, of a fibrous polymeric matrix for a period of time sufficient to obtain ingrowth of fibrous tissue and/or blood vessels, which is the removed for subsequent implantation at the site where the implant is desired. The matrix is optionally seeded prior to the first implantation, after ingrowth of the fibrous tissue, or at the time of reimplantation. The time required for fibrous ingrowth typically ranges from days to weeks. The method is particularly useful in making valves and tubular structures, especially heart valves and blood vessels.

Engineering of strong, pliable tissues

A coded information reading device for reading code pattern displayed on a CRT display unit of a television receiver and for outputing information signals corresponding to the code pattern includes a suction cup to be attached to the surface of the CRT display unit and a photo sensor integrally installed in the suction cup for reading the code pattern displayed on the CRT display unit.

Device for reading patterns displayed on a display unit

1-Aryl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-ones of the general formula ##STR1## wherein: R 1 is hydrogen, lower alkyl, preferably of 1-3 carbons, or unsaturated lower alkyl preferably of 2-3 carbons R 2 , R 3 , R 4 , R 5 are the same or different and are each hydrogen, halogen, lower alkyl, preferably methyl, lower alkoxy, preferably methoxy, or trifluoromethyl, and R 6 , R 7 , R 8 , R 9 are the same or different and are each hydrogen or lower alkyl, preferably methyl. The compounds are prepared by dehydrohalogenating substituted 2-(3'-halogenopropionylamino)-diphenyl amines of the general formula ##STR2## wherein R 2 to R 9 are the same as defined above and X is halogen, in the presence of a solvent and a base, to cyclize the amines and then alkylating to introduce the unsaturated lower alkyl radical R 1 on the nitrogen in the 5 position, if necessary. The compounds possess anticonvulsant, sedative and muscle relaxant properties.

1,5'-Benzodiazepine-2-ones, pharmaceutical compositions thereof and method of use thereof

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1,5'-Benzodiazepine-2-ones, pharmaceutical compositions thereof and method of use thereof