Osamu Hayashida
University of Tokyo
15 Papers
49 Citations
Osamu Hayashida is an academic researcher from University of Tokyo. The author has contributed to research in topics: Collagenase & Glucan. The author has an hindex of 6, co-authored 15 publications. Previous affiliations of Osamu Hayashida include Tokyo University of Agriculture.
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Papers
Collagen-derived peptides modulate CD4+ T-cell differentiation and suppress allergic responses in mice.
Akihiko Nishikimi,Yoh-ichi Koyama,Sayaka Ishihara,Shusaku Kobayashi,Chisa Tometsuka,Masashi Kusubata,Kumiko Kuwaba,Osamu Hayashida,Shunji Hattori,Koko Katagiri +9 more
TL;DR: The effects of collagen‐peptide ingestion on allergic response and the effects ofcollagen‐derived oligopeptides on CD4+ T‐cell differentiation are tested.
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Mutastein, a new inhibitor of adhesive-insoluble glucan synthesis by glucosyltransferases of Streptococcus mutans.
TL;DR: In the formation of glucans, that of adhesive water-insoluble glucans of S. mutans was specifically inhibited by mutastein, a heat-stable protein and was sensitive to pronase digestion.
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Characterization of Angiotensin-Converting Enzyme Inhibitory Activity of X-Hyp-Gly-Type Tripeptides: Importance of Collagen-Specific Prolyl Hydroxylation
Yuki Taga,Osamu Hayashida,Ahmed Ashour,Ahmed Ashour,Yhiya Amen,Yhiya Amen,Masashi Kusubata,Kiyoko Ogawa-Goto,Kuniyoshi Shimizu,Shunji Hattori +9 more
TL;DR: The strong ACE-inhibitory activity and high stability of X-Hyp-Gly-type tripeptides highlight their potential for hypertension control and demonstrated that prolyl hydroxylation significantly enhanced resistance to enzymatic degradation by incubation with mouse plasma.
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The C-terminal segment of collagenase in Grimontia hollisae binds collagen to enhance collagenolysis
TL;DR: A recombinant C‐terminal segment protein is produced and its ability to bind collagen and other characteristics as compared with collagen‐binding domains (CBDs) derived from Hathewaya histolytica collagenases are examined; these CBDs are the only ones thus far identified in bacterial collagenases.
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Patent
Dpp-4 inhibitor
Osamu Hayashida,Masashi Kusubata,Yuji Atsuzawa,Yuki Taga,Youichi Koyama,Shunji Hattori +5 more
- 02 Nov 2012
TL;DR: In this paper, a DPP-4 inhibitor containing, as an active ingredient, a peptide represented by formula (1): Xe-Pro/Ala/Hyp-Xa-Xb-Xc-Xd) is presented.
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