Orly Barak
13 Papers
Orly Barak is an academic researcher. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 2, co-authored 4 publications.
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Papers
Absent LH signaling rescues the anxiety phenotype in aging female mice
Steven Sims,Orly Barak,Vitaly Ryu,Sari Miyashita,H. W. Kannangara,Funda Korkmaz,Soleil Wizman,Anne MacDonald,Anisa Gumerova,Ki Ann Goosens,Mone Zaidi,Tony Yuen,Daria Lizneva,Tal Frolinger +13 more
TL;DR: The data collectively document, for the first time, that loss of LH signaling reverses age–related emotional disturbances, a prelude to future targeted therapies that block LH action.
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Optimizing a therapeutic humanized follicle‐stimulating hormone–blocking antibody formulation by protein thermal shift assay
Damini Sant,Satish Rojekar,Sakshi Gera,Anusha R. Pallapati,Judit Giménez-Roig,Tan-Chun Kuo,Ashley Padilla,Funda Korkmaz,Liam Cullen,Jiya Chatterjee,Eleanor Shelly,Marcia Meseck,Sari Miyashita,Anne MacDonald,Farhath Sultana,Orly Barak,Vitaly Ryu,Se-Min Kim,Cemre Robinson,Clifford J. Rosen,John Caminis,Daria Lizneva,Shozeb Haider,Tony Yuen,Mone Zaidi +24 more
TL;DR: In this paper , the authors used a protein thermal shift assay in which rising temperatures resulted in the maximal unfolding of the protein at the melting temperature (Tm), and optimized different sets of excipient combinations to yield a thermally stable formulation for the humanized follicle-stimulating hormone (FSH) blocking antibody, MS−Hu6.
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Development and Biophysical Characterization of a Humanized FSH–Blocking Monoclonal Antibody Therapeutic Formulated at an Ultra–High Concentration
Satish Rojekar,Anusha R. Pallapati,Judit Giménez-Roig,Funda Korkmaz,Farhath Sultana,Damini Sant,Clement M. Haeck,Anne MacDonald,Se-Min Kim,Clifford J. Rosen,Orly Barak,Marcia Meseck,John Caminis,Daria Lizneva,Tony Yuen,Mone Zaidi +15 more
TL;DR: In this paper , the authors report the creation of a unique formulation for their first-in-class FSH-blocking humanized antibody, MS-Hu6, which they propose to move to the clinic for osteoporosis, obesity, and Alzheimer's disease.
Gene–Dose–Dependent Reduction Fshr Expression Improves Spatial Memory Deficits in Alzheimer’s Mice
Funda Korkmaz,Steven Sims,Fazilet Sen,Farhath Sultana,Victoria Laurencin,Liam Cullen,Anusha R. Pallapati,Avi Liu,Satish Rojekar,George Penev,Ulliana Cheliadinova,Darya Vasilyeva,Guzel Burganova,Anne MacDonald,Mansi Saxena,Ki A. Goosens,Clifford Rosen,Orly Barak,Daria Lizneva,Anisa Gumerova,Keqiang Ye,Vitaly Ryu,Tony Yuen,Tal Frolinger,Mone Zaidi +24 more
TL;DR: The data provide compelling genetic evidence for a protective effect of inhibiting FSH signaling on the progression of spatial and recognition memory deficits in mice, and lay a firm foundation for the use of an FSH–blocking agent for the early prevention of cognitive decline in postmenopausal women.
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Fshr gene depletion prevents recognition memory loss, fat accrual and bone loss in Alzheimer's mice.
Uliana Cheliadinova,Steven Sims,Funda Korkmaz,Darya Vasilyeva,Victoria Laurencin,Judit Giménez-Roig,G. Pevnev,Guzel Burganova,Zehra Tumoglu,Surabhi Parte,Farhath Sultana,Anusha R. Pallapati,Satish Rojekar,Anne MacDonald,Susan Hutchison,Avi Soussan,Anchine Liu,Yi Wei,Ofer Moldavski,A. Gumerova,Weibin Zhou,Orly Barak,Ki A. Goosens,Vitaly Ryu,Daria Lizneva,Clifford Rosen,Tony Yuen,Tal Frolinger,Mone Zaidi +28 more