Örjan Carlborg
Uppsala University
137 Papers
963 Citations
Örjan Carlborg is an academic researcher from Uppsala University. The author has contributed to research in topics: Quantitative trait locus & Genetic architecture. The author has an hindex of 42, co-authored 136 publications. Previous affiliations of Örjan Carlborg include The Roslin Institute & Swedish University of Agricultural Sciences.
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Papers
Whole-genome resequencing reveals loci under selection during chicken domestication
Carl-Johan Rubin,Michael C. Zody,Michael C. Zody,Jonas Eriksson,Jennifer R. S. Meadows,Ellen Sherwood,Matthew T. Webster,Liang Jiang,Max Ingman,Ted Sharpe,Sojeong Ka,Finn Hallböök,Francois Besnier,Örjan Carlborg,Bertrand Bed'Hom,Michèle Tixier-Boichard,Per Jensen,Paul B. Siegel,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Leif Andersson,Leif Andersson +21 more
TL;DR: The authors used massively parallel sequencing to identify selective sweeps of favorable alleles and candidate mutations that have had a prominent role in the domestication of domestic chickens and their subsequent specialization into broiler (meat-producing) and layer (egg-consuming) chickens.
Epistasis: too often neglected in complex trait studies?
Örjan Carlborg,Chris Haley +1 more
TL;DR: It is argued that epistasis should be accounted for in complex trait studies; current study designs for detecting epistasis are critically assessed and how these might be adapted for use in additional populations, including humans.
The origin of the domestic pig: independent domestication and subsequent introgression.
TL;DR: Clear evidence was obtained for domestication to have occurred independently from wild boar subspecies in Europe and Asia, and the data indicated a hybrid origin of some major "European" pig breeds.
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Strong signatures of selection in the domestic pig genome
Carl-Johan Rubin,Hendrik-Jan Megens,Alvaro Martinez Barrio,Khurram Maqbool,Shumaila Sayyab,Doreen Schwochow,Chao Wang,Örjan Carlborg,Patric Jern,Claus Jørgensen,Alan Archibald,Merete Fredholm,Martien A. M. Groenen,Leif Andersson +13 more
TL;DR: The authors used whole-genome resequencing to reveal some of the loci that underlie phenotypic evolution in European domestic pigs, including the NR6A1, PLAG1, and LCORL genes.
Epistasis and the release of genetic variation during long-term selection.
TL;DR: It is shown that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci that mediate a considerably larger selection response than predicted by a single-locus model.
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