Oriol Fornes
University of British Columbia
48 Papers
34 Citations
Oriol Fornes is an academic researcher from University of British Columbia. The author has contributed to research in topics: Biology & Transcription factor. The author has an hindex of 13, co-authored 37 publications. Previous affiliations of Oriol Fornes include Health Science University & Pompeu Fabra University.
Chat about Author
Papers
On the prediction of DNA-binding preferences of C2H2-ZF domains using structural models: application on human CTCF
Alberto Meseguer,Filip Årman,Oriol Fornes,Ruben Molina-Fernández,Jaume Bonet,Narcis Fernandez-Fuentes,Narcis Fernandez-Fuentes,Baldo Oliva +7 more
TL;DR: A computational method is developed to predict the DNA-binding preferences of many members of the C2H2-ZF family, including the human chromatin binding factor CTCF.
Automated structure-based learning to model co-operativity and protein-DNA interactions in cis -regulatory modules
Oriol Fornes,Joaquim Aguirre-Plans,Gohl,Mireia-Bota,Molina-Fernández,Jaume Bonet,Chinchilla,Pegenaute,Gallego,Fernandez-Fuentes +9 more
TL;DR: A structure-based learning approach to predict the binding preferences of TFs and a web server to automatically model higher-order TF regulatory complexes (ModCRE) is introduced, which improves prediction accuracy when using an enrichment selection system that uses many neighbors or structure-models.
A GO catalogue of human DNA-binding transcription factors
Ruth C. Lovering,Pascale Gaudet,Marcio Luis Acencio,Marcio Luis Acencio,Alex Ignatchenko,Arttu Jolma,Oriol Fornes,Martin Kuiper,Ivan V. Kulakovskiy,Astrid Lægreid,Maria Jesus Martin,Colin Logie +11 more
TL;DR: A new curated catalogue of human DNA-binding transcription factors, including factors that regulate transcription, is produced to aid researchers investigating the regulation of transcription in both biomedical and basic science.
Altered transcription factor binding events predict personalized gene expression and confer insight into functional cis-regulatory variants
TL;DR: TF2Exp is presented, the first gene-based framework to predict the impact of altered TF binding on personalized gene expression based on cis-regulatory variants, and has the unique advantages to evaluate impact of uncommon variants and distinguish the functional roles of variants in linkage disequilibrium.
A GO catalogue of human DNA-binding transcription factors.
Ruth C. Lovering,Pascale Gaudet,Marcio Luis Acencio,Alex Ignatchenko,Arttu Jolma,Oriol Fornes,Martin Kuiper,Ivan V. Kulakovskiy,Ivan V. Kulakovskiy,Astrid Lægreid,Maria Jesus Martin,Colin Logie +11 more
TL;DR: The COST Action Gene Regulation Ensemble Effort for the Knowledge Commons (GREEKC) Consortium brought together experts in the field of transcription with the aim of providing high quality and interoperable gene regulatory data as discussed by the authors.