Olivier Messina
University of Montpellier
10 Papers
30 Citations
Olivier Messina is an academic researcher from University of Montpellier. The author has contributed to research in topics: Chromatin & Genome. The author has an hindex of 3, co-authored 5 publications. Previous affiliations of Olivier Messina include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Papers
Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms
Andrés M. Cardozo Gizzi,Diego I. Cattoni,Jean-Bernard Fiche,Sergio Martín Espínola,Julian Gurgo,Olivier Messina,Christophe Houbron,Yuki Ogiyama,Giorgio L. Papadopoulos,Giacomo Cavalli,Mounia Lagha,Marcelo Nollmann +11 more
TL;DR: The ability of Hi-M to explore the multi-scale chromosome architecture with spatial resolution at different stages of development or during the cell cycle will be key to understanding the mechanisms and consequences of the 4D organization of the genome.
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Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development.
Sergio Martín Espínola,Markus Götz,Maelle Bellec,Olivier Messina,Olivier Messina,Jean-Bernard Fiche,Christophe Houbron,Matthieu Dejean,Ingolf Reim,Andrés M. Cardozo Gizzi,Mounia Lagha,Marcelo Nollmann +11 more
TL;DR: In this article, a single-cell spatial genomics approach was employed to detect CRM-promoter looping interactions within topologically associating domains (TADs) during early Drosophila development.
Multiple parameters shape the 3D chromatin structure of single nuclei at the doc locus in Drosophila
TL;DR: In this article , the authors used Hi-M, a multiplexed DNA-FISH imaging technique providing developmental timing and transcriptional status, to show that the emergence of TADs at the ensemble level partially segregates the conformational space explored by single nuclei during the early development of Drosophila embryos.
Microscopy-based chromosome conformation capture enables simultaneous visualization of genome organization and transcription in intact organisms
Andrés M. Cardozo Gizzi,Diego I. Cattoni,Jean-Bernard Fiche,Sergio Martín Espínola,Julian Gurgo,Olivier Messina,Christophe Houbron,Yuki Ogiyama,Giorgio L. Papadopoulos,Giacomo Cavalli,Mounia Lagha,Marcelo Nollmann +11 more
TL;DR: Hi-M was used to study chromosome organization during the awakening of the zygotic genome in intact Drosophila embryos and was able to unveil the changes in 3D chromatin organization occurring upon transcriptional activation and homologous chromosome un-pairing.
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Qudi-HiM: an open-source acquisition software package for highly multiplexed sequential and combinatorial optical imaging
F. Barho,Jean-Bernard Fiche,Marion Bardou,Olivier Messina,Alexandre Martinière,Christophe Houbron,Marcelo Nollmann +6 more
TL;DR: Qudi-HiM, a modular software package written in Python 3.0, contains modules to automate the robust acquisition of thousands of three-dimensional multicolor microscopy images, the handling of microfluidics devices, and the remote monitoring of ongoing acquisitions and real-time analysis.
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