Oliver J. Rando
University of Massachusetts Medical School
171 Papers
508 Citations
Oliver J. Rando is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 65, co-authored 158 publications. Previous affiliations of Oliver J. Rando include Stanford University & Harvard University.
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Papers
Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex.
TL;DR: It is shown that the mammalian SWI/SNF-like BAF complex binds to phosphatidylinositol 4,5-bisphosphate (PIP2) micelles and PIP2-containing mixed lipid vesicles, and that PIP 2 binding allows the complex to associate with actin pointed ends and branch points.
242
Distinct Pathways for snoRNA and mRNA Termination
Minkyu Kim,Lidia Vasiljeva,Oliver J. Rando,Alexander Zhelkovsky,Claire Moore,Stephen Buratowski +5 more
TL;DR: Results suggest that in yeast the transcribing RNA polymerase II can choose between two distinct termination mechanisms but keeps both options available during elongation.
217
Developmentally induced changes in transcriptional program alter spatial organization across chromosomes
TL;DR: Examination of changes in nuclear organization that accompany stimulus by the mating pheromone alpha factor found that most alpha-factor-induced genes become associated with components of the nuclear envelope and the myosin-like protein Mlp1, which has been implicated in mRNA export, was further shown to exhibit RNA dependence in its association with alpha-Factor- induced genes.
Systematic evaluation of chromosome conformation capture assays.
Betul Akgol Oksuz,Liyan Yang,Sameer Abraham,Sergey V. Venev,Nils Krietenstein,Krishna Mohan Parsi,Hakan Ozadam,Hakan Ozadam,Marlies E. Oomen,Ankita Nand,Hui Mao,Ryan M.J. Genga,René Maehr,Oliver J. Rando,Leonid A. Mirny,Leonid A. Mirny,Johan H. Gibcus,Job Dekker,Job Dekker +18 more
TL;DR: In this paper, an improved Hi-C protocol (Hi-C 3.0) was proposed to detect both loops and compartments relatively effectively. But the performance of this protocol was limited by the cross-linking chemistry and chromatin fragmentation strategies.
R-loops regulate promoter-proximal chromatin architecture and cellular differentiation
TL;DR: R loops, RNA-DNA hybrids consisting of nascent transcripts hybridized to template DNA, modulate the binding of two key chromatin-regulatory complexes, Tip60–p400 and polycomb repressive complex 2, in mouse embryonic stem cells (ESCs).