Oliver J. Rando
University of Massachusetts Medical School
171 Papers
508 Citations
Oliver J. Rando is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 65, co-authored 158 publications. Previous affiliations of Oliver J. Rando include Stanford University & Harvard University.
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Papers
Chromatin remodelling at promoters suppresses antisense transcription
TL;DR: It is shown that Isw2 repositions nucleosomes to enforce directionality on transcription by preventing transcription initiation from cryptic sites, revealing how chromatin is organized on a global scale and advance the understanding of how transcription is regulated.
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Global regulation of H2A.Z localization by the INO80 chromatin remodeling enzyme is essential for genome integrity
TL;DR: Genetic interactions between ino80 and htz1 support a model in which INO80 catalyzes the removal of unacetylated H2A.Z from chromatin as a mechanism to promote genome stability.
476
High-resolution nucleosome mapping reveals transcription-dependent promoter packaging
TL;DR: A pipeline for analyzing deep sequencing maps of chromatin structure is introduced and evidence for highly sensitive nucleosomes located within "nucleosome-free regions" is found, suggesting that these regions are not always completely naked but instead are likely associated with easily digesteducleosomes.
Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm
Upasna Sharma,Fengyun Sun,Colin C. Conine,Brian Reichholf,Shweta Kukreja,Veronika A. Herzog,Stefan L. Ameres,Oliver J. Rando +7 more
TL;DR: Characterizing small RNA dynamics during germ cell maturation in mice confirms and extends prior observations that sperm undergo a dramatic switch in the RNA payload from piRNAs to tRNA fragments (tRFs) upon exiting the testis and entering the epididymis, and demonstrates that soma-germline RNA transfer occurs in male mammals.
396
Genome-wide views of chromatin structure
Oliver J. Rando,Howard Y. Chang +1 more
TL;DR: The use of genomic technologies to characterize chromatin structure in vivo is discussed, with a focus on data from budding yeast and humans, where the typical behavior gives insight into the mechanisms and deep rules that establish Chromatin structure.
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