Oliver J. Rando
University of Massachusetts Medical School
171 Papers
508 Citations
Oliver J. Rando is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 65, co-authored 158 publications. Previous affiliations of Oliver J. Rando include Stanford University & Harvard University.
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Papers
Single-nucleosome mapping of histone modifications in S. cerevisiae.
Chih Long Liu,Tommy Kaplan,Minkyu Kim,Stephen Buratowski,Stuart L. Schreiber,Nir Friedman,Oliver J. Rando +6 more
TL;DR: It is found that histone modifications do not occur independently; there are roughly two groups of co-occurring modifications that are consistent with the idea of a simple, redundant histone code, in which multiple modifications share the same role.
Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding.
Tsung-Han S. Hsieh,Claudia Cattoglio,Elena Slobodyanyuk,Anders S. Hansen,Oliver J. Rando,Robert Tjian,Xavier Darzacq +6 more
TL;DR: This study uncovers previously obscured finer-scale genome organization, establishing functional links between chromatin folding and gene regulation by using high-resolution Micro-C to probe links between 3D genome organization and transcriptional regulation in mouse stem cells.
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Ultrastructural Details of Mammalian Chromosome Architecture
Nils Krietenstein,Sameer Abraham,Sergey V. Venev,Nezar Abdennur,Johan H. Gibcus,Tsung-Han S. Hsieh,Krishna Mohan Parsi,Liyan Yang,René Maehr,Leonid A. Mirny,Job Dekker,Oliver J. Rando +11 more
TL;DR: A recently developed Hi-C variant, Micro-C, is extended to map chromosome architecture at nucleosome resolution in human ESCs and fibroblasts, providing a valuable resource for studies of chromosome organization.
548
Mbd3/NURD Complex Regulates Expression of 5-Hydroxymethylcytosine Marked Genes in Embryonic Stem Cells
Ozlem Yildirim,Ruowang Li,Jui-Hung Hung,Poshen B Chen,Xianjun Dong,Ly-Sha Ee,Zhiping Weng,Oliver J. Rando,Thomas G. Fazzio +8 more
TL;DR: The roles of several chromatin regulators whose loss affects the pluripotent state of ES cells are examined, and it is found that Mbd3 and Brg1 antagonistically regulate a common set of genes by regulating promoter nucleosome occupancy.
490
Timescales of Genetic and Epigenetic Inheritance
TL;DR: Recent findings suggest that organisms have evolved mechanisms to influence the timing or genomic location of heritable variability, suggesting that selection and variability are less independent than once thought.
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