Oliver J. Rando
University of Massachusetts Medical School
171 Papers
508 Citations
Oliver J. Rando is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 65, co-authored 158 publications. Previous affiliations of Oliver J. Rando include Stanford University & Harvard University.
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Papers
Deep sequencing of yeast and mouse tRNAs and tRNA fragments using OTTR
H. Tobias Gustafsson,Carolina Galan,Tianxiong Yu,Heather Upton,Lucas Ferguson,Ebru Kaymak,Zhiping Weng,Kathleen Collins,Oliver J. Rando +8 more
TL;DR: Applying this protocol to mature mouse spermatozoa, the data dramatically alter the understanding of the small RNA cargo of mature mammalian sperm, revealing a far more complex population of tRFs – including both 5’ and 3’ tRNA halves derived from the majority of tRNAs – than previously appreciated.
Histone exchange is associated with activator function at transcribed promoters and with repression at histone loci
TL;DR: Evidence is provided that histone exchange at gene promoters is not simply a consequence of PIC assembly or transcription but instead is mediated by activators, and it is shown that not all activators up-regulate gene expression by inducing histone turnover.
A synthetic biology approach to probing nucleosome symmetry
Yuichi Ichikawa,Caitlin F. Connelly,Alon Appleboim,Thomas C. Miller,Hadas Jacobi,Nebiyu Abshiru,Hsin-Jung Chou,Yuanyuan Chen,Upasna Sharma,Yupeng Zheng,Paul M. Thomas,Hsiuyi V. Chen,Vineeta Bajaj,Christoph W. Müller,Neil L. Kelleher,Nir Friedman,Daniel N. Bolon,Oliver J. Rando,Paul D. Kaufman +18 more
TL;DR: The ability to generate asymmetric nucleosomes in vivo and in vitro provides a powerful and generalizable tool to probe the mechanisms by which H3 tails are read out by effector proteins in the cell.
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Patent
Proteasome regulation of NF-KB activity
Vito J. Palombella,Alfred L. Goldberg,Tom Maniatis,Oliver J. Rando +3 more
- 17 Mar 1995
TL;DR: In this article, a method for regulating the activity of NF-λB in an animal comprising contacting cells of the animal with certain proteasome inhibitors is described, and the method is shown to be effective in the case of mice.
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