Oliver J. Rando
University of Massachusetts Medical School
171 Papers
508 Citations
Oliver J. Rando is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 65, co-authored 158 publications. Previous affiliations of Oliver J. Rando include Stanford University & Harvard University.
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Papers
A key role for chd1 in histone h3 dynamics at the 3' ends of long genes in yeast
Marta Radman-Livaja,Tiffani K. Quan,Lourdes Valenzuela,Jennifer A. Armstrong,Tibor van Welsem,TaeSoo Kim,Laura J. Lee,Stephen Buratowski,Fred van Leeuwen,Oliver J. Rando,Grant A. Hartzog +10 more
TL;DR: Using genome-wide ChIP-on-chip analysis, a role for Chd1 in histone replacement in both budding yeast and Drosophila melanogaster is found, and surprisingly they show that the major effects of Chd 1 on turnover occur at the 3′ ends of genes.
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Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF
Sarah J. Hainer,Weifeng Gu,Benjamin R. Carone,Benjamin D. Landry,Oliver J. Rando,Craig C. Mello,Thomas G. Fazzio +6 more
TL;DR: It is shown that the ability of a strongly positioned nucleosome to repress ncRNA depends on its translational positioning, and this data reveal a novel role for esBAF in suppressing pervasive transcription from open chromatin regions in ESCs.
An atlas of cell types in the mouse epididymis and vas deferens
Vera D. Rinaldi,Elisa Donnard,Kyle Gellatly,Morten Rasmussen,Alper Kucukural,Onur Yukselen,Manuel Garber,Upasna Sharma,Oliver J. Rando +8 more
TL;DR: A single-cell atlas of the murine epididymis and vas deferens is generated, which recovers key epithelial cell types including principal cells, clear cells, and basal cells, along with associated support cells that include fibroblasts, smooth muscle, macrophages and other immune cells.
RNA polymerase II dynamics shape enhancer-promoter interactions.
Gilad Barshad,James J. Lewis,Alexandra G. Chivu,Abderhman Abuhashem,Nils Krietenstein,Edward J. Rice,Yitian Ma,Zhong Wang,Oliver J. Rando,Anna-Katerina Hadjantonakis,Charles G. Danko +10 more
TL;DR: Perturbation of RNA polymerase II (Pol II) via chemical inhibition or dTAG-induced degradation and analysis using Micro-C and run-on sequencing show that enhancer–promoter contacts are dependent on transcription and stabilized by paused RNA Pol II.
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Ultrastructural details of mammalian chromosome architecture
Nils Krietenstein,Sameer Abraham,Sergey V. Venev,Nezar Abdennur,Johan H. Gibcus,Tsung-Han S. Hsieh,Krishna Mohan Parsi,Liyan Yang,René Maehr,Leonid A. Mirny,Job Dekker,Job Dekker,Oliver J. Rando +12 more
TL;DR: A recently-developed Hi-C variant is extended, Micro-C, to map chromosome architecture at nucleosome resolution in human embryonic stem cells and fibroblasts, providing the highest resolution maps of chromosome folding in human cells to date.
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