Oliver E Yausep
Newcastle University
3 Papers
Oliver E Yausep is an academic researcher from Newcastle University. The author has contributed to research in topics: Navitoclax & Inflammation. The author has an hindex of 1, co-authored 3 publications.
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Papers
Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery.
Emily Dookun,Anna Walaszczyk,Rachael Redgrave,Pawel Palmowski,Simon Tual-Chalot,Averina Suwana,James Chapman,Eduard Jirkovsky,Leticia Donastorg Sosa,Eleanor K Gill,Oliver E Yausep,Yohan Santin,Jeanne Mialet-Perez,W. Andrew Owens,David J. Grieve,Ioakim Spyridopoulos,Michael J. Taggart,Helen M. Arthur,João F. Passos,Gavin D. Richardson +19 more
TL;DR: It is demonstrated that IRI induces cellular senescence in both cardiomyocytes and interstitial cell populations and treatment with the senolytic drug navitoclax after ischemia–reperfusion improves left ventricular function, increases myocardial vascularization, and decreases scar size.
Clearance of senescent cells during cardiac ischemia-reperfusion injury improves heart recovery following myocardial infarction
Emily Dookun,Anna Walaszczyk,Rachael Redgrave,Pawel Palmowski,Simon Tual-Chalot,Averina Suwana,James Chapman,Eduard Jirkovsky,Leticia Donastorg Sosa,Eleanor K Gill,Oliver E Yausep,Yohan Santin,Jeanne Mialet-Perez,W. Andrew Owens,David J. Grieve,Ioakim Spyridopoulos,Michael J. Taggart,Helen M. Arthur,João F. Passos,Gavin D. Richardson +19 more
TL;DR: This study provides proof-of-concept evidence that cellular senescence contributes to impaired heart function and adverse remodeling following cardiac ischemia-reperfusion and establishes that post-IRI the SASP plays a considerable role in the inflammatory response.
Clearance of senescent cells following cardiac ischemia-reperfusion injury improves recovery
Emily Dookun,Anna Walaszczyk,Rachael Redgrave,Pawel Palmowski,Simon Tual-Chalot,Averina Suwana,James Chapman,Eduard Jirkovsky,Leticia Donastorg Sosa,Eleanor K Gill,Oliver E Yausep,Yohan Santin,Jeanne Mialet-Perez,W. Andrew Owens,David J. Grieve,Ioakim Spyridopoulos,Michael J. Taggart,Helen M. Arthur,João F. Passos,Gavin D. Richardson +19 more
TL;DR: It is demonstrated that IRI induces cellular senescence in both cardiomyocytes and interstitial cell populations and treatment with the senolytic drug navitoclax after ischemia-reperfusion improves left ventricular function, increases myocardial vascularization, and decreases scar size.