Oliver B. Davis
University of California, Berkeley
9 Papers
2 Citations
Oliver B. Davis is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Lysosome & Biology. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Oliver B. Davis include University of California.
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Papers
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex
Brian M. Castellano,Ashley M. Thelen,Ofer Moldavski,McKenna Feltes,Reini E. N. van der Welle,Laurel Mydock-McGrane,Xuntian Jiang,Robert J. van Eijkeren,Oliver B. Davis,Sharon M. Louie,Rushika M. Perera,Douglas F. Covey,Daniel K. Nomura,Daniel S. Ory,Roberto Zoncu +14 more
TL;DR: Cholesterol is identified, an essential building block for cellular growth, as a nutrient input that drives mTORC1 recruitment and activation at the lysosomal surface and the SLC38A9-NPC1 complex, which is key to the ability of m TORC1 to respond to variations in dietary lipid supply.
ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
Chun Yan Lim,Oliver B. Davis,Hijai R. Shin,Justin Zhang,Charles A. Berdan,Xuntian Jiang,Jessica L. Counihan,Daniel S. Ory,Daniel K. Nomura,Roberto Zoncu +9 more
TL;DR: ER–lysosome contacts are signalling hubs that enable cholesterol sensing by mTORC1, and targeting the sterol-transfer activity of these signalling hubs could be beneficial in patients with NPC.
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Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.
Chiara Di Malta,Diletta Siciliano,Alessia Calcagni,Jlenia Monfregola,Simona Punzi,Nunzia Pastore,Andrea N. Eastes,Oliver B. Davis,Rossella De Cegli,Angela Zampelli,Luca Giovanni Di Giovannantonio,Edoardo Nusco,Nick Platt,Alessandro Guida,Margret H. Ogmundsdottir,Luisa Lanfrancone,Rushika M. Perera,Roberto Zoncu,Pier Giuseppe Pelicci,Pier Giuseppe Pelicci,Carmine Settembre,Andrea Ballabio +21 more
TL;DR: It is found that MiT/TFE transcription factors—master regulators of lysosomal and melanosomal biogenesis and autophagy—control mTORC1 lysOSomal recruitment and activity by directly regulating the expression of RagD, resulting in cell hyperproliferation and cancer growth.
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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Oliver B. Davis,Hijai R. Shin,Chun-Yan Lim,Emma Y. Wu,Matthew Kukurugya,Claire F. Maher,Rushika M. Perera,M. Paulina Ordonez,Roberto Zoncu +8 more
TL;DR: Cholesterol-mTORC1 signaling controls organelle homeostasis and is a targetable pathway in Niemann-Pick type C and consistently ameliorates mitochondrial dysfunction in a neuronal model of NPC.
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Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
Hijai R. Shin,Y. Rose Citron,Lei Wang,Laura Tribouillard,Claire Goul,Robin Stipp,Yusuke Sugasawa,Aakriti Jain,Nolwenn Samson,Chun-Yan Lim,Oliver B. Davis,David Castaneda-Carpio,Ming-Yi Qian,Daniel K. Nomura,Rushika M. Perera,Eun Young Park,Douglas F. Covey,Mathieu Laplante,Alex S. Evers,Roberto Zoncu +19 more
TL;DR: This work has identified LYCHOS, a multidomain transmembrane protein that enables cholesterol-dependent activation of the master growth regulator, the protein kinase mechanistic Target of Rapamycin Complex 1 (mTORC1).
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