Olena Ohlei
University of Lübeck
16 Papers
2 Citations
Olena Ohlei is an academic researcher from University of Lübeck. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 6 publications.
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Papers
Critical evaluation of the DNA-methylation markers ABCG1 and SREBF1 for Type 2 diabetes stratification
Christin Krause,Helen Sievert,Cathleen Geißler,Martina Grohs,Alexander T. El Gammal,Stefan Wolter,Olena Ohlei,Fabian Kilpert,Ulrike M. Krämer,Meike Kasten,Christine Klein,Georg Brabant,Oliver Mann,Hendrik Lehnert,Henriette Kirchner +14 more
TL;DR: DNA methylation at both loci in blood presents a promising approach for risk group stratification and could be valuable for personalized Type 2 diabetes risk prediction in the future.
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In situ detection of PR3-ANCA+ B cells and alterations in the variable region of immunoglobulin genes support a role of inflamed tissue in the emergence of auto-reactivity in granulomatosis with polyangiitis.
Gesche Weppner,Olena Ohlei,Christoph M. Hammers,Konstanze Holl-Ulrich,Jan Voswinkel,Julia Bischof,Katrin Hasselbacher,Gabriela Riemekasten,Peter Lamprecht,Saleh M. Ibrahim,C. Iking-Konert,Andreas Recke,Antje Müller +12 more
TL;DR: The results suggest that with respect to a local anti-PR3 response, methods detecting rare clones are required, and primary and probably secondary rearrangements led to altered VDJ usage and an extended complementarity determining region 3 (CDR3) of IGHV clones from GPA tissue.
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Common signatures of differential microRNA expression in Parkinson’s and Alzheimer’s disease brains
Valerija Dobricic,Marcel Schilling,I. Farkas,Djordje Gveric,Olena Ohlei,Jessica Schulz,Lefkos T. Middleton,Steve M. Gentleman,Laura Parkkinen,Lars Bertram,Christina M. Lill +10 more
TL;DR: This study quantified the expression of the four most compelling PD candidate miRNAs from these meta-analyses in the superior temporal gyrus (STG) of one of the largest case-control post-mortem brain datasets available, thereby quadruplicating previously investigated sample sizes.
Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans
Y. Sommerer,Valerija Dobricic,Marcel Schilling,Olena Ohlei,David Bartrés-Faz,Gabriele Cattaneo,Ilja Demuth,Sandra Düzel,Sören Franzenburg,Janina Fuss,Ulman Lindenberger,Alvaro Pascual-Leone,Sanaz Sedghpour Sabet,Cristina Solé-Padullés,José María Tormos,Valentin Max Vetter,Tanja Wesse,Andre Franke,Christina M. Lill,Lars Bertram +19 more
TL;DR: The authors conducted an epigenome-wide association study (EWAS) using DNA methylation (DNAm) profiles from buccal and blood samples for cross-sectional and longitudinal changes in episodic memory performance (n = 626; average follow-up time 5.4 years).
No increase of CD8+ TEMRA cells in the blood of healthy adults at high genetic risk of Alzheimer's disease.
Laura Deecke,Jan Homann,David Goldecktble,Olena Ohlei,Valerija Dobricic,Johanna Drewelies,I. Demuth,Graham Pawelec,Lars Bertram,Christina M Lill +9 more
TL;DR: This study investigated whether the alteration of TEMRA cells may manifest even earlier in the course of the disease, that is, in younger and in older, cognitively healthy adults at high genetic risk of AD based on polygenic risk score (PRS) analyses.
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