Oleksandr Brener
University of Düsseldorf
18 Papers
93 Citations
Oleksandr Brener is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Chemistry & P3 peptide. The author has an hindex of 12, co-authored 18 publications. Previous affiliations of Oleksandr Brener include Forschungszentrum Jülich.
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Papers
Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice.
Susanne Aileen Funke,Thomas van Groen,Inga Kadish,Dirk Bartnik,Luitgard Nagel-Steger,Oleksandr Brener,Torsten Sehl,Renu Batra-Safferling,Christine Moriscot,Guy Schoehn,Anselm H. C. Horn,Andreas Müller-Schiffmann,Carsten Korth,Heinrich Sticht,Dieter Willbold +14 more
TL;DR: In vitro and in vivo properties of the Aβ targeting d-enantiomeric amino acid peptide D3 are reported and it is suggested that next to plaque load and inflammation reduction, oral application of the peptide improved the cognitive performance of AD transgenic mice and thereby supports their decisive role in AD development and progression.
Combining independent drug classes into superior, synergistically acting hybrid molecules.
Andreas Müller-Schiffmann,Julia März-Berberich,Aksana Andreyeva,Raik Rönicke,Dirk Bartnik,Oleksandr Brener,Janine Kutzsche,Anselm H. C. Horn,Marco Hellmert,Jolanta Polkowska,Kurt Gottmann,Klaus G. Reymann,S. Aileen Funke,Luitgart Nagel-Steger,Christine Moriscot,Guy Schoehn,Heinrich Sticht,Dieter Willbold,Thomas Schrader,Carsten Korth +19 more
TL;DR: It is reasoned that if the target molecule of two independent classes of drugs was the same, chemical synthesis of a hybrid compound where these drugs presented moieties within one molecule might yield synergistic effects; that is, a new quality might emerge that would be more than the sum of the singlemoiety compounds.
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Double-strand DNA end-binding and sliding of the toroidal CRISPR-associated protein Csn2
Zihni Arslan,Reinhild Wurm,Oleksandr Brener,Philipp Ellinger,Luitgard Nagel-Steger,Filipp Oesterhelt,Lutz Schmitt,Dieter Willbold,Rolf Wagner,Holger Gohlke,Sander H. J. Smits,Ümit Pul +11 more
TL;DR: The results demonstrate that the ring-shaped Csn2 tetramer binds DNA ends through its central hole and slides inward, likely by a screw motion along the helical path of the enclosed DNA.
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QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers
Oleksandr Brener,Tina Dunkelmann,Lothar Gremer,Thomas van Groen,Ewa A. Mirecka,Inga Kadish,Antje Willuweit,Janine Kutzsche,Dagmar Jürgens,Stephan Rudolph,Markus Tusche,Patrick Bongen,Jörg Pietruszka,Jörg Pietruszka,Filipp Oesterhelt,Karl-Josef Langen,Hans-Ulrich Demuth,Arnold Janssen,Wolfgang Hoyer,Susanne Aileen Funke,Luitgard Nagel-Steger,Dieter Willbold +21 more
TL;DR: The predictive power of the assay for in vivo efficacy is demonstrated by comparing the oligomer elimination efficiency of D3 and D3D3 with their treatment effects in animal models of Alzheimer´s disease.
Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer's Disease.
Janine Kutzsche,Sarah Schemmert,Markus Tusche,Jörg Neddens,Roland Rabl,Dagmar Jürgens,Oleksandr Brener,Antje Willuweit,Birgit Hutter-Paier,Dieter Willbold +9 more
TL;DR: It is proven that the lead compound “D3”, an all d-enantiomeric-peptide, specifically eliminates Aβ oligomers in vitro, and a complete reversal of the cognitive deficit of APPSL mice is demonstrated.
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