Obinna Mbachu
University of Illinois at Chicago
5 Papers
1 Citations
Obinna Mbachu is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Chemistry & Isoxanthohumol. The author has an hindex of 3, co-authored 5 publications.
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Papers
The Multiple Biological Targets of Hops and Bioactive Compounds.
Judy L. Bolton,Tareisha L. Dunlap,Atieh Hajirahimkhan,Obinna Mbachu,Shao-Nong Chen,Luke Chadwick,Dejan Nikolic,Richard B. van Breemen,Guido F. Pauli,Birgit M. Dietz +9 more
TL;DR: Understanding the biological targets of hop dietary supplements and their phytoconstituents will ultimately lead to standardized botanical products with higher efficacy, safety, and chemopreventive properties.
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SAR Study on Estrogen Receptor α/β Activity of (Iso)flavonoids: Importance of Prenylation, C-Ring (Un)Saturation, and Hydroxyl Substituents
Obinna Mbachu,Caitlin E. Howell,Charlotte Simmler,Gonzalo R. Malca Garcia,Kornelia J. Skowron,Huali Dong,Sarah G. Ellis,Ryan T. Hitzman,Atieh Hajirahimkhan,Shao-Nong Chen,Dejan Nikolic,Terry W. Moore,Terry W. Moore,Günter Vollmer,Günter Vollmer,Guido F. Pauli,Judy L. Bolton,Birgit M. Dietz +17 more
TL;DR: Botanicals with ERβ-preferential flavonoids could plausibly contribute to ER β-protective benefits in menopausal women.
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Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication
Atieh Hajirahimkhan,Obinna Mbachu,Charlotte Simmler,Sarah G. Ellis,Huali Dong,Dejan Nikolic,David C. Lankin,Richard B. van Breemen,Shao-Nong Chen,Guido F. Pauli,Birgit M. Dietz,Judy L. Bolton +11 more
TL;DR: The data suggest that standardization of G. inflata to 3 might enhance the safety and efficacy of postmenopausal women’s health supplements used for menopausal symptom relief, while ERβ activation could enhance safety by opposing ERα effects.
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Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation
Shuai Wang,Tareisha L. Dunlap,Caitlin E. Howell,Obinna Mbachu,Emily A. Rue,RS Phansalkar,Shao-Nong Chen,Guido F. Pauli,Birgit M. Dietz,Judy L. Bolton +9 more
TL;DR: Data show that the hop extract and 6-PN preferentially enhance the nontoxic estrogen 2-hydroxylation pathway through AhR mediated up-regulation of P450 1A1, which further emphasizes the importance of standardization of botanical extracts to multiple chemical markers for both safety and desired bioactivity.