O'Sullivan Ma
Trinity College, Dublin
5 Papers
98 Citations
O'Sullivan Ma is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Semliki Forest virus & Virus. The author has an hindex of 5, co-authored 5 publications.
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Papers
The pathogenicity of the A7, M9 and L10 strains of Semliki Forest virus for weanling mice and primary mouse brain cell cultures.
TL;DR: The virulence of the L10 strain is due to its ability to exceed a lethal threshold of damage to neurons before immune intervention can occur, and it is proposed that infection of glial cells triggers immune-mediated demyelination.
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Teratogenicity of the Semliki Forest virus mutant ts22 for the foetal mouse: induction of skeletal and skin defects.
M. J. E. M. F. Mabruk,A. M. Flack,Gwendoline M. Glasgow,J. M. B. Smyth,J. C. Folan,J. G. Bannigan,O'Sullivan Ma,Brian J. Sheahan,Gregory J. Atkins +8 more
TL;DR: It is proposed that the skeletal and skin defects induced in mouse foetuses by ts22 infection result from the tropism of the virus for mesenchymal cells involved in the development of such tissue.
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Effect of infection with the ts22 mutant of Semliki Forest virus on development of the central nervous system in the fetal mouse.
M. J. E. M. F. Mabruk,G M Glasglow,A. M. Flack,J. C. Folan,J. G. Bannigan,J. M. B. Smyth,O'Sullivan Ma,Brian J. Sheahan,Gregory J. Atkins +8 more
TL;DR: It was shown that the skin and musculoskeletal systems of fetuses from mothers infected with ts22 were often heavily infected but the central nervous systems were not labeled before day 17 of pregnancy, which appeared to be indirect and caused by virus infection of mesenchymal cells surrounding the developing neural tube.
Infection of Cultured Early Mouse Embryos with Semliki Forest and Rubella Viruses
TL;DR: Four- and eight-cell embryos could not be infected with rubella virus (RV), even after removal of the zona pellucida, and infection of zona-free blastocysts resulted in a productive but non-cytolytic infection which did not affect embryonic development to the early egg-cylinder stage.
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Isolation and preliminary characterization of Semliki Forest virus mutants with altered pathogenicity for mouse embryos.
TL;DR: It is concluded that infections of pregnant mice with ts14 and ts22 in particular are good models for analysis of the mechanism of virus-induced developmental defects.
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