Nuno Sepúlveda
University of Lisbon
91 Papers
386 Citations
Nuno Sepúlveda is an academic researcher from University of Lisbon. The author has contributed to research in topics: Malaria & Population. The author has an hindex of 27, co-authored 91 publications. Previous affiliations of Nuno Sepúlveda include University of Peshawar & Instituto Superior de Ciências da Saúde Egas Moniz.
Chat about Author
Papers
A central role for free heme in the pathogenesis of severe sepsis.
Rasmus Larsen,Raffaella Gozzelino,Viktória Jeney,László Tokaji,Fernando A. Bozza,André M. Japiassú,Dolores Bonaparte,Moisés Marinho Cavalcante,Ângelo Chora,Ana Ferreira,Ivo Marguti,Silvia Cardoso,Nuno Sepúlveda,Nuno Sepúlveda,Ann Smith,Miguel P. Soares +15 more
TL;DR: Protective effect of this heme-catabolizing enzyme relies on its ability to prevent tissue damage caused by the circulating free heme released from hemoglobin during infection, and it is proposed that targeting freeHeme by HPX might be used therapeutically to treat severe sepsis.
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
Ayush Giri,Jacklyn N. Hellwege,Jacob M. Keaton,Jacob M. Keaton,Jihwan Park,Chengxiang Qiu,Helen R. Warren,Helen R. Warren,Eric S. Torstenson,Eric S. Torstenson,Csaba P. Kovesdy,Yan V. Sun,Otis D. Wilson,Otis D. Wilson,Cassianne Robinson-Cohen,Christianne L. Roumie,Cecilia P. Chung,K A Birdwell,K A Birdwell,Scott M. Damrauer,Scott L. DuVall,Derek Klarin,Kelly Cho,Yu Wang,Evangelos Evangelou,Evangelos Evangelou,Claudia P. Cabrera,Claudia P. Cabrera,Louise V. Wain,Louise V. Wain,Rojesh Shrestha,Brian S. Mautz,Elvis A. Akwo,Muralidharan Sargurupremraj,Stéphanie Debette,Michael Boehnke,Laura J. Scott,Jian'an Luan,Zhao J-H.,Sara M. Willems,Sébastien Thériault,Nabi Shah,Nabi Shah,Christopher Oldmeadow,Peter Almgren,Ruifang Li-Gao,Niek Verweij,Thibaud Boutin,Massimo Mangino,Massimo Mangino,Ioanna Ntalla,Elena V. Feofanova,Praveen Surendran,James P. Cook,Savita Karthikeyan,Najim Lahrouchi,Ching-Ti Liu,Nuno Sepúlveda,Tom G. Richardson,Aldi T. Kraja,Philippe Amouyel,Martin Farrall,Neil Poulter,Markku Laakso,Eleftheria Zeggini,Peter S. Sever,Robert A. Scott,Claudia Langenberg,Nicholas J. Wareham,David Conen,Palmer Cna.,John Attia,Daniel I. Chasman,Paul M. Ridker,Olle Melander,Dennis O. Mook-Kanamori,Harst Pvd.,Francesco Cucca,David Schlessinger,Caroline Hayward,Tim D. Spector,Jarvelin M-R.,Branwen J. Hennig,Branwen J. Hennig,Nicholas J. Timpson,Wei W-Q.,J C Smith,Yaomin Xu,Michael E. Matheny,E E Siew,C M Lindgren,C M Lindgren,C M Lindgren,Herzig K-H.,George Dedoussis,Josh C. Denny,Bruce M. Psaty,Howson Jmm.,Patricia B. Munroe,Patricia B. Munroe,Christopher Newton-Cheh,Mark J. Caulfield,Mark J. Caulfield,Paul Elliott,Paul Elliott,J M Gaziano,J M Gaziano,John Concato,Wilson Pwf.,Philip S. Tsao,D.R. Velez Edwards,D.R. Velez Edwards,Katalin Susztak,Christopher J. O'Donnell,Adriana M. Hung,Adriana M. Hung,Todd L. Edwards,Todd L. Edwards +117 more
TL;DR: Analysis of blood pressure data from the Million Veteran Program trans-ethnic cohort identifies common and rare variants, and genetically predicted gene expression across multiple tissues associated with systolic, diastolic and pulse pressure in over 775,000 individuals.
451
Reappraisal of known malaria resistance loci in a large multicenter study.
Kirk A. Rockett,Geraldine M. Clarke,Kathryn Fitzpatrick,Christina Hubbart,Anna E. Jeffreys,Kate Rowlands,Rachel Craik,M Jallow,David J. Conway,Kalifa Bojang,Margaret Pinder,Stanley Usen,Fatoumatta Sisay-Joof,Giorgio Sirugo,Ousmane Touré,Mahamadou A. Thera,Salimata Konate,Sibiry Sissoko,Amadou Niangaly,Belco Poudiougou,Valentina D. Mangano,Edith C. Bougouma,Sodiomon B. Sirima,David Modiano,L. Amenga-Etego,Anita Ghansah,Kwadwo A. Koram,Michael D. Wilson,Anthony Enimil,Jennifer R Evans,Olukemi K. Amodu,Subulade A. Olaniyan,Tobias O. Apinjoh,Regina N. Mugri,Andre Ndi,Carolyne M. Ndila,Sophie Uyoga,Alexander Macharia,Norbert Peshu,Thomas N. Williams,Alphaxard Manjurano,Eleanor M. Riley,Chris Drakeley,Hugh Reyburn,Vysaul Nyirongo,David Kachala,Malcolm E. Molyneux,Sarah J. Dunstan,Nguyen Hoan Phu,Nguyen Ngoc Quyen,Cao Quang Thai,Tran Tinh Hien,Laurens Manning,Moses Laman,Peter Siba,Harin Karunajeewa,Steve Allen,Angela Allen,Timothy M. E. Davis,Pascal Michon,Ivo Mueller,Angie Green,Síle F. Molloy,Kimberly J. Johnson,Angeliki Kerasidou,Victoria Cornelius,Lee Hart,Aaron Vanderwal,Miguel A. Sanjoaquin,Gavin Band,Si Quang Le,Matti Pirinen,Nuno Sepúlveda,Chris C. A. Spencer,Taane G. Clark,Tsiri Agbenyega,Eric A. Achidi,Ogobara K. Doumbo,Jeremy Farrar,Kevin Marsh,Terrie E. Taylor,Dominic P. Kwiatkowski +81 more
TL;DR: The finding that G6PD deficiency has opposing effects on different fatal complications of P. falciparum infection indicates that the evolutionary origins of this common human genetic disorder are more complex than previously supposed.
European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe.
Luis Nacul,François Jérôme Authier,Carmen Scheibenbogen,Lorenzo Lorusso,Ingrid B. Helland,Jose Alegre Martin,Carmen Adella Sirbu,Anne Marit Mengshoel,Olli Polo,Uta Behrends,Henrik Nielsen,Patricia Grabowski,Slobodan Sekulic,Nuno Sepúlveda,Fernando Estévez-López,Paweł Zalewski,Derek Pheby,Jesús Castro-Marrero,Giorgos K. Sakkas,Enrica Capelli,Ivan Brundsdlund,John Cullinan,Angelika Krumina,Jonas Bergquist,Modra Murovska,Ruud C W Vermuelen,Eliana M Lacerda +26 more
TL;DR: The European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has received funding from the European Cooperation in Science and Technology (COST)-COST action 15111-from 2016 to 2020 as discussed by the authors.
150
Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.
C M Ndila,Sophie Uyoga,Alexander Macharia,Gideon Nyutu,Norbert Peshu,John Ojal,Mohammed Shebe,Kennedy O. Awuondo,Neema Mturi,Benjamin Tsofa,Nuno Sepúlveda,Taane G. Clark,Geraldine M. Clarke,Kate Rowlands,Christina Hubbart,Anna E. Jeffreys,Silvia N. Kariuki,Kevin Marsh,Margaret J. Mackinnon,Kathryn Maitland,Dominic P. Kwiatkowski,Kirk A. Rockett,Thomas N. Williams,Thomas N. Williams +23 more
TL;DR: In this paper, a case-control study in Kilifi County, Kenya was conducted to investigate associations between multiple candidate polymorphisms and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress.
111